Evaluation of thiol/disulfide homeostasis in patients with acne vulgaris

Abstract

AimAcne vulgaris (AV) is a chronic, multifactorial, inflammatory disease of the pilosebaceous unit. In this study, we compare the dynamic thiol/disulfide homeostasis (TDH) of patients with AV with that of control subjects.MethodIn this study, the dynamic TDH in patients with AV was measured and compared with that of the control subjects using the method following Erel and Neselioglu. 74 patients with AV and 60 age- and gender-matched healthy subjects were included. Ethical approval and informed consent were obtained. Patients with chronic inflammatory diseases, alcohol/tobacco use, or pregnancy/lactation were excluded.ResultsThe patient group comprised 38 female and 36 male patients, and the control group comprised 29 female and 31 male subjects. Total thiol levels were significantly lower in patients with AV than in the control subjects (P = .044), and the disulfide/total thiol ratio was significantly lower in patients with AV (P = .034). Plasma native thiol, total thiol, and disulfide levels did not differ significantly between subgroups of mild, moderate, and severe disease (P > .05).ConclusionTo our knowledge, this is the first study to evaluate TDH in patients with AV. Plasma thiol levels, an important component of the antioxidant system, are significantly lower in AV, indicating that antioxidant systems are affected by inflammatory diseases.

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