Antimicrobial activities of essential oils on microorganisms isolated from radiation dermatitis

Abstract

AimThe aim of this study was to investigate the antimicrobial effect of essential oils obtained from Mediterranean region plants on microorganisms isolated as secondary skin infections in patients with Grade II and III acute radiation dermatitis.MethodsThe antimicrobial activity of essential oils, Origanum vulgare (O. vulgare), Lavandula intermedia (L. intermedia), and Thymus vulgaris (T. vulgaris) were evaluated by broth microdilution method on microorganisms isolated from 20 patients with Grade II and III radiation dermatitis. Microdilutions were modified according to The Clinical and Laboratory Standards Institute (CLSI) recommendations and the lowest concentration which inhibited growth after incubation was identified as Minimal Inhibitory Concentration (MIC). The severity degree of acute radiation dermatitis was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.03.ResultsNine pathogenic strains were isolated from 20 samples of the patients. The pathogens included Methicillin-resistant Staphylococcus aureus (MRSA), methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant coagulase-negative Staphylococcus (MRCNS), methicillin-sensitive coagulase-negative Staphylococcus (MSCNS), Klebsiella pneumoniae (K. pneumoniae), and Candida albicans (C. albicans). MIC values for each essential oil against these microorganisms were determined and the essential oils were found effective against the isolates.ConclusionO. vulgare, L. intermedia, and T. vulgaris essential oils demonstrated antimicrobial activity against pathogens isolated from secondary infections of radiation dermatitis. Future use of essential oils in the treatment of acute radiation dermatitis should be considered.

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