Matrix metalloproteinases and oxidative stress in patients with AECOPD

Abstract

AimThe aim of this study was to determine the relationship between oxidative status, matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2) and tissue metallopeptidase inhibitor-1 (TIMP-1) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD).MethodsThe study included a total of 35 patients with acute exacerbated COPD and 35 healthy nonsmoker controls. We assessed the concentrations of MMP-2, MMP-9, TIMP-1, total antioxidant status (TAS), and total oxidant status (TOS) in the study population.ResultsMMP-9 concentrations were found as 201.19±12.91 pg/mL and 189.32±13.01 pg/mL in patients and controls, respectively. TAS concentrations were found as 20.27± 2.99 μmol trolox equiv/l and 17.69±2.96 μmol trolox equiv/l in patients and controls, respectively. Significant differences were found between patients and controls in terms of MM9 and TAS (< .001) concentrations. We also found lower TIMP-1 concentrations in patients (P = .035) than controls. We also found correlation between MMP-9, TAS (r = 0.484, P < .001) and the oxidative status index (r = 0.221, P < .001). However, we did not find any significant correlation between MMP-2, TIMP-1, and oxidative stress markers (TAS and TOS). ConclusionIt is thought that the antioxidant treatment approaches could be beneficial for AECOPD patients for preventing the MMP-9 related inflammation.

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