Co-occurrence of helicobacter pylori and intestinal metaplasia in patients with dyspepsia

Abstract

AimHelicobacter pylori (HP) is a common gram negative bacteria associ-ated with peptic ulcer disease and malignancy. In this study we evaluated the co-occurrence of helicobacter pylori and intestinal metaplasia (IM) in pa-tients with dyspepsia.MethodWe retrospectively evaluated the gastroscopy and antral biopsy results of patients that were admitted to Siverek Government Hospital general surgery outpatient clinic with dys-pepsia between November 2013 and January 2015. Pathology samples were investigated with giemsa for HP and with PAS-AB for intestinal metaplasia.ResultsWe evaluated 682 patients (304 men, 378 women) with a mean age of 38.22 ±14.64 years (range 18-88 years). We diagnosed 555 (81.4%) with antral gastritis, 81 (11.9%) with pangastritis, and 6 (0.9%) with ulcero-vegetant tumoral lesion. Based on pathology we diagnosed 469 (69.6%) with chronic gastritis, 201 (29.5%) with inactive chronic gastritis, and 6 (0.9%) with adenocarcinoma. HP was detected in 475 (69.6%) patients, intestinal metaplasia was detected in 56 (8.2%) patients, and atrophy was seen in 11 (1.6%) patients. HP was detected in 4 (66.6%) of the 6 patients with adeno-carcinoma. In 48 patients with HP, intestinal metaplasia was also found. In 8 patients with intestinal metaplasia, HP was negative. Co-occurrence of HP and intestinal metaplasia was statistically significant (p: 0.006).ConclusionHP promotes intestinal metaplasia. The prevention and treatment of HP pre-vents precancerous lesions. In particular, patients with dyspepsia resistant to medical treatment should be examined carefully in general surgery practice.

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