Alterations of thyroid hormone levels in cadmium exposure

Abstract

AimEnvironmental chemicals and heavy metals may alter thyroid hormone levels via several mechanisms, including disruption of iodine (I) transport, thyroid peroxi¬dase, thyroid hormone-binding proteins, hepatic catabolism, deiodinases, and receptor binding. Our aim was to investigate the change in thyroid hormone levels in cadmium exposure.MethodPainters, welders, miners, and smelters with an occupational exposure of more than 10 years, aged between 18-70 years, were divided into six groups according to whole blood cadmium levels (Group 1: 0-0.5 μg/L; Group 2: 0.5-1 μg/L; Group 3: 1-1.5 μg/L; Group 4: 1.5-2 μg/L; Group 5: 2-2.5 μg/L; Group 6: >2.5 μg/L).ResultsThere was a positive correlation between cadmium and serum free thyroxine and triiodothyronine levels. There was a negative correlation be-tween cadmium and serum alanine aminotransferase and vitamin B12 levels.ConclusionCadmium exposure was found to lead to an increase in thyroid hormone levels.

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