Investigation of prolidase, adenosine deaminase, glutathione s-transferase and glutathione reductase activities in patients with abortus imminens

Abstract

AimAbortus Imminens is a pregnancy-related disease, the pathophysiol-ogy of which has not yet been thoroughly determined. The aim of this study was to investigate possible relations between prolidase (PR) enzyme activ-ity and adenosine deaminase (ADA), glutathione S-transferase (GST) and glutathione reductase (GR) activities in Abortus Imminens patients.MethodFifty patients with Abortus Imminens were examined in İpekyolu Women’s and Children’s Hospital between June 2015 and Septem-ber 2015. The age range of the patients selected was between 18 and 50. Prolidase (PR) enzyme activity and adenosine deaminase (ADA), glutathione S-transferase(GST) and glutathione reductase (GR) activities were measured in Abortus Imminens serums. Prolidase (PR), adenosine deaminase (ADA), glutathione-S-transferase (GST) and glutathione reductase (GR) activities were determined by spectrophotometry.ResultsGlutathione S-transferase and glutathione reductase activities were found to be significantly decreased in Abortus Imminens patients compared to healthy subjects.ConclusionChanges in antioxidant enzyme activities may play a very important role in the pathogenesis of Abortus Imminens.The serum ADA levels can be used as a biochemical marker in Abortus Imminens. This is the first large-scale study in the literature of the relationship between Abortus Imminens and antioxidants.

Keywords

Additional Information

Publisher’s Note
Bayrakol MP remains neutral with regard to jurisdictional and institutional claims.

Rights and Permissions

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of the license, visit https://creativecommons.org/licenses/by-nc/4.0/

View full license details →