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Plasma MDA levels, GSH-Px activities and nitrite/nitrate levels in patients with familial Mediterranean fever

Familial Mediterranean fever and oxidative stress

Original Research • doi:10.4328/JCAM.10.1.11 • Published: January 1, 2010

Authors

Ahmet Tüzün1, Bülent Değertekin1, Zeki Yeşilova1, İlkin Naharcı2, Ayşe Eken3, Ahmet Aydın3, Ahmet Uygun1, Ahmet Sayal3
Affiliations

1Department of Gastroenterology, Gulhane Military Medical Academy, Ankara, Türkiye.

2Department of Internal Medicine, Gulhane Military Medical Academy, Ankara, Türkiye.

3Department of Pharmaceutical Sciences, Gulhane Military Medical Academy, Ankara, Türkiye.

Corresponding Author

Ahmet Tüzün

Abstract

AimOne of the genetic diseases known to adversely affect endothelial function is familial Mediterranean fever (FMF). The purpose of this study is to investigate the status of oxidative stress and nitric oxide (NO)-related parameters in patients with FMF.
MethodsForty-one subjects with FMF (38 male, 3 female) and 32 healthy control subjects (29 male, 3 female) were selected from Turkish population. Glutathione peroxidase (GSH-Px), malondialdehyde (MDA), and nitrite/nitrate (NO₂⁻/NO₃⁻) levels were investigated in all subjects.
ResultsMDA and NO₂⁻/NO₃⁻ levels of patients in the acute phase were significantly higher than those of control (p < 0.001). No significant difference was found in GSH-Px activities between in the acute phase patients and the control subjects. MDA and NO₂⁻/NO₃⁻ levels of patients in the attack-free period were also significantly higher than those of control (p < 0.001). No significant difference was found between the patients in the attack-free period and the control according to GSH-Px activities.
ConclusionOur findings points out that oxidative status and NO metabolism is affected in FMF patients. High MDA and NO₂⁻/NO₃⁻ levels in the attack-free phase of patients may be due to the certain period of time needed for the relief of lipid peroxidation and the reversal of NO pathway activation.

Keywords

familial Mediterranean fever oxidative stress nitric oxide

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About This Article

Received:
July 27, 2009
Accepted:
August 28, 2009
Published Online:
January 1, 2010
Printed:
January 1, 2010