Synthesis and antimicrobial activity of novel heterocycles containing thiazolidinone and 1,3,4-oxadiazole moieties

Abstract

Aim To design, synthesize and characterize a new series of 7-(4-((substituted)5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)-4-(phenylamino)-9(trichloromethyl)-1-thia-4,7,8-triazaspiro[4.4]non-8-ene-3,6-di one and evaluate for antimicrobial activity.Methods All title compounds were structurally elucidated on the basis of spectroscopic and elemental analysis. The antimicrobial screening was carried out by employing cup plate method. The zone of inhibition (mm) of each compound was determined and compared with that of standard drug.Results The relationship between the substituent group and the biological activity of the compounds was discussed.Conclusion While all the compounds exhibited moderate antibacterial activity, VIIa, VIIb and VIIc were found to be better antibacterial agents and VIId, VIIe and VIIf were found to be superior antifungal agents than the other title compounds.

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