Interactions of theophylline with drug, diet, some xenobiotics, and habits and their toxicological outcomes

Abstract

In vitro and in vivo interactions which are commonly met during drug therapy and their toxicological outcomes are important. In order to increase effect of certain drugs, interactions, which are called as beneficial interactions, are intentionally applied. However, examples of these interactions are in limited number. On the other hand, untoward and hazardous interactions that cause very important outcomes in toxicological point of view are common. These types of interactions develop more easily during therapy with drugs have a narrow therapeutic window. Theophylline which is used in the treatment of asthma and chronic obstructive pulmonary disease (COPD) has also a nar-row therapeutic window. Therefore, in the present review, some important examples resulted from interactions of theophylline with drug, diet, xenobi-otic, herbal product, habits and their toxicological outcomes have been given.

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