Effect of local puerarin administration on xenograft

Abstract

AimThe purpose of this study was to investigate the healing potential of local puerarin administration on xenograft in cranial bone defect treatment in rats.MethodA critical-size defect of 5-mm diameter was created in the calvarium of twenty-four rats. The animals were divided into three groups: group C (passive control), group XBG (treated with Bio-Oss), and group P-XBG (treated with puerarin + Bio-Oss combination). All animals were euthanized at 28 days postoperative. Stereologic analyses were per-formed. New bone area and connective tissue volumes were measured.ResultsMean new bone volumes were 1.57 ± 0.13mm3, 1.24 ± 0.10 mm3, and 0.31 ± 0.09 mm3 in groups P-XBG, XBG and C respectively. The new bone volumes were statistically significant in groups P-XBG and XBG compared to group C (p ≤ 0.05). Moreover, the new bone formation in group P-XBG was statistically higher when compared to the XBG group (P<0.05). In the P-XBG group, mean connective tissue volume was 2.00 ± 0.12 mm3. The connective tissue volumes were statistically higher in groups P-XBG and XBG compared to group C (p<0.05). The difference between group P-XBG and group XBG was also statistically significant (p<0.05).ConclusionPuerarin had a positive effect on xenograft and increased new bone formation.

Keywords

Additional Information

Publisher’s Note
Bayrakol MP remains neutral with regard to jurisdictional and institutional claims.

Rights and Permissions

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of the license, visit https://creativecommons.org/licenses/by-nc/4.0/

View full license details →