Physiological uptake of 18F-fluorodeoxyglucose in PET/CT imaging: a frequent diagnostic pitfall

Abstract

Even normal physiological conditions can cause elevated fluorine-18 fluoro-deoxyglucose (FDG) uptake in several locations, such as the brain, heart, skel-etal muscle, urinary system, gastrointestinal system, brown fat, lymphatic tissue, liver, spleen, thyroid gland, thymus, tongue, salivary glands, breast tissue, gonads, uterus, and bone marrow. Detailed knowledge of physiological FDG uptake is crucial for correct evaluation of positron emission tomogra-phy/computed tomography images and for avoiding false-positive diagno-ses. Proper measures should be taken to decrease physiological FDG uptake as much as possible.

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