The relationship of hypertrophic Cardiomyopathy and micro-rna’s

Abstract

AimHypertrophic cardiomyopathy (HCM) is a heart muscle disease which primarily causes myocardial hypertrophy. MicroRNAs(miRNA) are small RNAs which involved in the regulation of protein synthesis in the cell and circula-tion. In this study, 11 micro-RNAs shown in the literature to be associated with cardiac hypertrophy were investigated in peripheral blood by looking at the expression of miRNA level whether it is specific to hypertrophic car-diomyopathy or not.Method26 patients with HCM, 25 pa-tients with hypertension (HT) and 24 subjects of control group referred to our department between March 2012 and March 2013 were enrolled into this study. Blood samples were taken, and 11 miRNAs’ expression levels were analyzed by the RT-PCR method. miRNA expression levels were compared between three groups.ResultsmiR-1, miR-21, miR-22, miR-23a miR-29, miR-30, miR-34, miR-133 and miR-199a expression levels were not different between groups (p>0,05). miR-208 and miR-290 levels have not been evalu-ated because of inadequate expression.ConclusionmiR-1, miR-21, miR-22, miR-23a, miR-29, miR-30, miR-34, miR-133 and miR-199a expression levels did not show any difference in HCM, HT and control group.

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