The effect of oxaliplatin on heart tissue of the rats

Abstract

AimThis study investigates the cardiotoxicity of Oxaliplatin (OXA) on rat heart by using oxidative stress parameters on myocardium and troponin I and S100A1 levels of serum.MethodAcute OXA treatment (4 mg/kg/1st, 3rd and 5th days) has been administered to the 6-8 months old rats. The heart and serum samples were obtained at 7th and 14th days of the study. Chronic OXA treatment was (4 mg/kg/two days of week/4 weeks) administered, rats were sacrificed and heart and serum samples were obtained at the 28th day and at the 2st day following the completing administration of drugs.ResultsThe results of all OXA treatment group’s antioxidant levels and serum cardiotoxicity markers; troponin I and S100 A1 levels were not significantly different compared to the control group (p>0.05).ConclusionOXA did not produce significant oxidative myocardial damage when given 4 mg/kg in acute and chronic administration. Oxa treatment seems safe in terms of cardiotoxicity.

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