Serum transaminase elevation in Patients with rotavirus gastroenteritis

Abstract

AimIn the present study we aimed to assess the relationship between rotavirus gastroenteritis and mean platelet volume, serum alanine amino-transferase, aspartate aminotransferase, and diarrhea score. MethodThis study enrolled pediatric patients aged one month to 16 years who were diagnosed with gastroenteritis and hospitalized for rehydration between January 2016 and July 2016. Patients who had rotavirus positive gastroenteritis were grouped as RPGE group, and those with rotavirus nega-tive gastroenteritis were grouped as RNGE group. Subjects who were hospi-talized at pediatric surgery unit for simple surgical procedures were grouped as the control group. ResultsMean AST and ALT levels of the RPGE group were significantly greater than those of the RNGE group (p:0.001; p<0.05). Twenty-one (52.5%) patients in the RPGE group had AST elevation alone while 7 (17.5%) had elevation in both ALT and AST. In the RNGE group, 9 (15%) patients had AST elevation alone, and 4 (6.7%) had elevations in both ALT and AST. The RPGE and RNGE groups had significantly greater CRP and WBC levels compared to the control group (p<0.05). RPGE and RNGE groups had no statistically significant difference in either parameter (p>0.05). There were no significant differences between the groups regarding PCT, MPV, and PLT levels (p>0.05). The mean diarrhea score of the RPGE group were signifi-cantly greater than those of the RNGE group (p:0.001; p<0.05). A significant positive correlation was found between the gastroenteritis score and PLT, AST, and ALT levels (p<0.05). ConclusionBy means of the present study we determined that rotavirus gastroenteritis was correlated to elevated serum transaminase levels. We would like to stress that rotavirus infection should be remembered in children with acute gastroenteritis and elevated trans-aminases.

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