Effect of preemptive epidural analgesia in percutaneous nephrolithotomy

Abstract

AimThe present study aimed to compare stress response, hemodynamic changes, and postoperative analgesic requirements of general anesthesia and preemptive epidural analgesia added to general anesthesia in patients who will receive Percutaneous Nephrolithotomy (PNL).MethodThere were 50 patients undergoing PNL. Patients were randomly distributed into two groups: Group A: General anesthesia (GA) group (induction; sevo-flurane + 50% O2+ air mixture + 2 μg/kg fentanyl) (n=25). Group E: Epi-dural analgesia (13 mL 0.25% levobupivacaine + 2 mL 100 μg fentanyl) + GA (induction; sevoflurane + 50% O2+ air mixture + 2 μg/kg fentanyl) (n=25). Demographic data, hemodynamic parameters, postoperative VAS values and analgesic consumption were compared among the groups.ResultsThe changes in glucose, insulin, cortisol, and C-reactive protein from the param-eters used in the present study to assess the neuroendocrine response to surgical stress were statistically similar in both groups (p>0.05). There was no statistically significant difference in the postoperative total analgesic consumption between the groups (p>0.05).ConclusionThe changes in stress and inflammatory response are prevented in the period during which the ef-ficacy of single-dose epidural analgesia continues; however, it remains inef-fective in the following periods.

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