Relationship between seasonal serum 25-hydroxyvitamin d levels and disease activity in patients with ankylosing spondylitis, osteoarthritis and fibromyalgia syndrome

Abstract

AimIn this study, we aimed to investigate the relationship between seasonal vitamin D levels and disease activity in patients with ankylosing spondylitis (AS), osteoarthritis (OA), fibromyalgia syndrome (FMS) and healthy controls.MethodThe study included 32 patients with AS, 25 patients with OA, 25 patients with FMS and 25 healthy controls. Bi-seasonal mea-surements of serum vitamin D were checked in July, August, and September for summertime and in December, January and February for wintertime. Dis-ease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), The Western Ontario and McMaster Universities Osteoar-thritis Index (WOMAC) and Fibromyalgia Impact Questionnaire (FIQ)-Hospital Anxiety and Depression Scale (HAD) in groups of AS, OA, and FMS patients respectively.ResultsIn our study, there was no statistically significant differ-ence between summer BASDAI values and winter BASDAI values in patients with AS (p> 0.05), and there was no relationship between vitamin D levels and BASDAI values. There was a statistically significant difference between summer WOMAC mean value and winter WOMAC mean value in OA group (p<0.05) and vitamin D levels were significantly lower in winter. There was a significant negative correlation between WOMAC values and vitamin D levels. In patients with FMS, there was a negative significant difference between FIQ values and seasonal vitamin D, but this relationship was not found be-tween HAD score and seasonal vitamin D levels.ConclusionEspecially in patients with OA and FMS, it is important to determine vitamin D levels and to provide supplementation to patients in terms of contributing to the regulation of disease activity.

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