Mediastinal granulomatous reaction in lung cancer in cappadocia region

Abstract

AimThis study aims to investigate the mediastinal granulomatous reactions detected during invasive staging in patients undergoing surgical treatment due to lung cancer in Cappadocia region.Method469 patients were included in the study who underwent surgical treatment for lung can-cer between 2003 and 2016 in Cappadocia region. Lymph node stations sampled by mediastinoscopy and thoracotomy were evaluated during the invasive staging of the patients.ResultsA total of 2637 (mean: 5.6) lymph node stations were sampled from 469 patients with mediastinoscopy and thoracotomy. 21 (4.4%) patients had a granulomatous reaction. The numbers of male and female patients were 17 and 4, respectively. The age of the pa-tients ranged from 52 to 73 years (mean 62.19 ± 7.5). It was determined that the most common type of cancer in patients with granulomatous reactions were squamous carcinoma (n = 9). Other common cancers were adenocar-cinoma (n = 7) and large cell (n = 2) carcinoma. Lymph node metastasis and sarcoidosis reaction association were found in two patients.ConclusionThe frequency of granulomatous reactions for lung cancer is 4.4% in Cappadocia region. Although the granulomatous reaction is more frequent in early stage disease, it may be seen in advanced stage patients and may accompany metastatic lymph nodes.

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