Platelet-lymphocyte ratio in predicting mortality of patients in pediatric intensive care unit

Abstract

Aim Patients in the PICU have high rates of mortality. In this study we researched whether platelet-lymphocyte ratio (PLR), in addition to other scoring methods, is an early predictor of mortality risk in PICU patients.Methods The patient files of children hospitalized in the PICU between 2014 and 2015 were examined.Results A total of 670 patients were included (46.9% girls and 53.1% boys). 25 (3.7%) of these children died. In patients who died, the GCS was below 9, and PRISM, PELOD, and PIM2 scores were above 12, 7, and 90, respectively (p<0.001 for each factor). Significant cut-off values were 2 (p<0.001) for lactate (100% sensitivity, 64.3% specificity) and 3.9 (p<0.001) for PLR (80% sensitivity, 68.9% specificity). Diagnoses such as hematological-oncological diseases, sepsis, or multi-organ failure in children admitted to the PICU were factors affecting mortality (p=0.001, p=0.008, and p<0.001, respectively). Other
factors affecting mortality were found to be high PIM2 scores (p=0.041), hyperlactatemia (p<0.001), and high PLR (p<0.001).Conclusion In addition to known scoring methods, PLR is a beneficial predictive factor of mortality rate in PICU patients.

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