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Does hepatic visualisation show residual/metastaticthyroid tissue in differentiated thyroid cancer?

Physiological hepatic visualisation in differentiated thyroid cancer

Original Research • doi:10.4328/JCAM.5838 • Published: January 1, 2019

Authors

Zekiye Hasbek1, Serdar Savaş Gul2, Esra Cıftcı3, Seyit Ahmet Erturk4, Ali Cakmakcılar1, Gülhan Duman4, Bülent Turgut5
Affiliations

1Department of Nuclear Medicine, School of Medicine, Cumhuriyet University, Sivas, Türkiye.

2Department of Nuclear Medicine, School of Medicine, Gaziosmanpaşa University, Tokat, Türkiye.

3Department of Nuclear Medicine, School of Medicine, Sakarya University, Sakarya, Türkiye.

4Department of Endocrinology, School of Medicine, Cumhuriyet University, Sivas, Türkiye.

5Department of Nuclear Medicine, School of Medicine, Katip Çelebi University, İzmir, Türkiye.

Corresponding Author

Zekiye Hasbek

hasbekz@yahoo.com

+90 533 611 17 50

Abstract

AimDiffuse homogen hepatic uptake in whole-body scan (WBS) after radioiodine remnant ablation (RRA) suggests that there is occult or visible remnant thyroid tissue and/or tumor tissue. It is thought that the reason is hepatic metabolization of radioiodine (¹³¹I) marked thyroglobulin fragments which are secreted by remnant/tumor tissue. The aims of this study were to investigate whether the hepatic visualisation after radioiodine remnant ablation showed the presence of metastatic or residual disease in patients with differentiated thyroid cancer and also to investigate whether early or late WBS after RRA (RxWBS) had an effect on the physiological hepatic uptake.
Method201 DTC patients were evaluated (F/M: 152/49; mean age: 49.61±13 years [range: 18–85 years]) who referred for RRA. The therapeutic ¹³¹I dose ranged from 100mCi to 200mCi. RxWBS was performed earlier (in 1-4th-day after RRA) in 106 patients (Group 1) and was performed later (in 5-9th-day after RRA) in 95 patients (Group 2).
ResultsDiffuse hepatic uptake were seen only in three patients (2.8%) and was not seen in 103 patients (97.2%) in Group 1. However, in Group 2 diffuse hepatic uptake was seen in 93 patients (97.9%) (p<0.05) and not seen only in 2 patients (2.1%). There is not a statistically significant relationship between the hepatic uptake and serum Tg, LT4 and TSH level. There is a statistically significant relationship between anti-Tg level and hepatic uptake.
ConclusionPhysiological diffuse hepatic uptake of radioiodine in WBS after RRA may not be seen during the early WBS. Thus, metastatic foci may be missed with early scanning. We conclude that RxWBS after RRA should be done in late period.

Keywords

differentiated thyroid cancer radioiodine hepatic uptake scintigraphy

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About This Article

Received:
March 28, 2018
Accepted:
April 27, 2018
Published Online:
April 28, 2018
Printed:
January 1, 2019