Predictive and prognostic value of preoperativecomplete blood count in prostate cancer

Abstract

Aim The predictive and prognostic value of complete blood count (CBC) in different types of cancer has been frequently demonstrated in recent years. Prostate cancer is the second most common cancer in men worldwide and is one of the most leading causes of death. In our study, we sought to find out whether CBC parameters could distinguish patients with prostate cancer from patients with benign prostatic hyperplasia.Method Laboratory findings and histopathological findings of totally 93 patients were retrospectively re-evaluated. The absolute neutrophil count (ANC), the absolute lymphocyte count (ALC),
platelet count, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) values were noted. In patients with prostate cancer, pathological parameters such as prostate weight, tumor percentage, Gleason score perineural invasion, seminal vesicle involvement, apical and radial margin involvement, extra-prostatic extension were determined.Results In our study, we found that ANC, NLR, PLR, and MPV were significantly different between patients with benign prostatic hyperplasia and with prostate cancer (p < 0.05). We found that ANC and MPV were much more successful in discriminating these patients (p < 0.001). We have shown that ANC has higher specificity and MPV value has higher sensitivity. However, we didn’t find any
correlation between blood parameters and pathological parameters in patients with prostate cancer.ConclusionOur study has shown that ANC, NLR, PLR, and MPV have the ability to discriminate malignant lesions from benign lesions. Although no correlation with pathologic parameters can be determined, we think that CBC might be evaluated as an auxiliary tool for prostate cancer diagnosis.

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