Study of the effects of spinorphin on painful diabetic neuropathy: A behavioral study in vivo
Department of Internal Medicine, Adıyaman University Training and Research Hospital Internal Diseases Clinic, Adıyaman, Turkey
DOI: 10.4328/ACAM.20475 Received: 2021-01-08 Accepted: 2021-01-25 Published Online: 2021-01-30 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):208-211
Corresponding Author: Erkan Cakmak, Department of Internal Medicine, Adıyaman University Training and Research Hospital Internal Diseases Clinic, Adıyaman, Turkey. E-mail: firstname.lastname@example.org P: +90 505 311 20 80 Corresponding Author ORCID ID: https://orcid.org/0000-0002-0442-0630
Aim: Diabetic neuropathy is one of the chronic complications of diabetes. Our aim in this study is to examine the effects of spinorphine on painful diabetic neuropathy in vivo. Material and Methods: Seventy-five three-week rats were used. The first group was determined as a healthy control group (n = 15). Then, diabetic animals were grouped into subassemblies following induction in rats induced streptozotocin and diabetes. Groups were created using rat as follows: First group: Healthy control group, Second group: Diabetic control group (group to be given spinorphine solvent) (n = 15), Third group: DM + SP0.1 group (group to be applied 0.1 mg / kg spinorphine) (n = 15), Fourth Group: DM + SP1 group (group to be applied 1 mg / kg spinorphine) (n = 15) and Fifth group: DM + SP5 group (group to be applied 5 mg / kg spinorphine) (n = 15).Results: When the diabetic control group and the healthy control group were compared in terms of the pain threshold values, a statistically significant dif-ference was found (P <0.05). This result was considered significant in regards to the development of neuropathy (P <0.05). The pain threshold values in DM + SP0.1 and DM + SP1 groups had no statistically significant differences compared with the diabetic control group (P> 0.05). Discussion: This study, found spinorphine to be effective at doses of 5mg/kg or higher and when administrated intraperitoneally in the acute antinociceptive treatment of painful neuropathy in diabetic rats.
Keywords: Diabetic neuropathy; Hot plate; Spinorphine
The effect of sufi music on sedation in patients under spinal anesthesia during orthopedic surgery
Ali Akdoğan, Mahmut Arslan, Nesrin Erceyes
Department of Anesthesiology and Critical Care, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
DOI: 10.4328/ACAM.20472 Received: 2021-01-07 Accepted: 2021-01-26 Published Online: 2021-01-29 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):204-207
Corresponding Author: Ali Akdogan, Karadeniz Technical University, Faculty of Medicine, Department of Anesthesiology and Critical Care, 61080, Trabzon, Turkey. E-mail: email@example.com P: +90 (462) 377 57 41 F: + 90 (462) 325 53 98 Corresponding Author ORCID ID: https://orcid.org/0000-0001-7592-3844
Aim: Music is the preferred method of sedation due to its noninvasive nature, affordable cost, and easy application. In this study, we aimed to compare music therapy with a control (non-music) group in terms of perioperative sedation requirements, anxiety levels, and patient satisfaction starting from the preopera-tive period in patients who underwent orthopedic surgery under spinal anesthesia.Material and Methods: This study was carried out prospectively with 50 patients in the ASA I-II risk group, aged 18-60 years and will undergo elective non-oncological orthopedic surgery. Patients taken to the preparation room were randomly classified into two groups. Propofol (FRESENIUS-Germany) infusion was started at 1 mg/kg/hour in patients who underwent spinal anesthesia in the operation room. The Bispectral Index Monitor™ (BIS) was used to verify sedation. Hemodynamic data and BIS values were recorded preoperatively (t1) and during spinal anesthesia (t2). Perioperative values were recorded at the 5th, 15th, 30th, 60th minute (t3, t4, t5, t6) and postoperative 30th minute (t7). Results: There was no statistically significant difference between patients’ demographic characteristics and the duration of surgery. Although lower values were detected in the music group in terms of heart rate (HR) and mean arterial pressure (MAP) at all times, the difference between the groups was not statistically significant. When evaluated in terms of BIS scores, significantly lower values were recorded in the music group at all times. When Ramsey Sedation Scores were compared, while high scores were obtained at t2 and after in the music group at all times, the results at t5, t6, t7 times were found to be significantly higher.Discussion: Our study showed that listening to Sufi music starting from the preoperative period has positive effects on anxiety. Considering the negative ef-fects of anxiety on the experience of anesthesia and operation success, it can be said that the more frequent use of a non-invasive method such as music can reduce the anxiety of the operation.
Keywords: Music therapy; Spinal anesthesia; Turkish sufi music; Perioperative anxiety
Evaluation of knowledge and attitudes of radiology department workers about artificial intelligence
Isil Yurdaisik 1, Suleyman Hilmi Aksoy 2
1 Department of Radiology, Istinye University Medical Park Gaziosmanpasa Hospital, 2 Department of Radiology, Hisar Intercontinental Hospital, Istanbul, Turkey
DOI: 10.4328/ACAM.20453 Received: 2020-12-24 Accepted: 2021-01-25 Published Online: 2021-01-28 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):186-190
Corresponding Author: Isil Yurdaisik, Department of Radiology, Istinye University Medical Park Gaziosmanpasa Hospital, Cukurcesme Street No: 57-59 Gaziosmanpasa, Istanbul, Turkey. E-mail: firstname.lastname@example.org P: +90 212 979 30 00 F: +90 212 979 30 00 Corresponding Author ORCID ID: https://orcid.org/0000-0001-8316-1229
Aim: The objective of this study was to investigate the knowledge and attitudes of radiology department workers through a survey.Material and Methods: In this study, the opinions and attitudes of physicians, residents and technicians working in radiology departments of various hospitals and medical students in our university about AI were collected through a survey conducted between 01/07/2020 and 12/08/2020 and analyzed through a survey.Results: The response rate of the survey was 25.3%; 47.1% of the participants reported that they have enough knowledge about AI applications in general, while only 25% stated that they hadsufficient knowledge about AI applications in radiology. Among all participants, 35.3% thought that AI applications would negatively affect the profession of radiologists, while 30.3% thought that these applications would have positive impacts; 51.9% of the participants think that AI applications will save time for radiologists. The rate of participants who were concerned about the advances in AI was 16.1%. Discussion: Further similar studies should be conducted on this issue in order to obtain more detailed information and contribute to the literature. We believe that our results will be guiding for further comprehensive studies on the opinions of radiology department workers about the use of AI in the field of radiology.
Keywords: Artificial intelligence; Radiology department; Imaging; Healthcare workers
The effect of positive end-expiratory pressure on optic nerve diameter in patients undergoing craniotomy operation
Ozlem Sezen 1, Kemal Tolga Saracoglu 1, Tahsin Şimşek 1, Banu Cevik 1, Evren Aydoğmuş 2
1 Department of Anesthesiology and Reanimation, University of Health Sciences, Kartal Dr.Lutfi Kırdar City Hospital, 2 Department of Neurosurgery University of Health Sciences, Kartal Dr. Lutfi Kırdar City Hospital, Istanbul, Turkey
DOI: 10.4328/ACAM.20469 Received: 2021-01-06 Accepted: 2021-01-22 Published Online: 2021-01-25 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):199-203
Corresponding Author: Ozlem Sezen, Department of Anesthesiology and Reanimation, University of Health Sciences, Kartal Dr.Lutfi Kırdar City Hospital, Istanbul, Turkey.E-mail: email@example.com P: +90 216 441 39 00 GSM: +90 532 391 82 98 Corresponding Author ORCID ID: https://orcid.org/0000-0002-2144-9224
Aim: In this study, we aimed to investigate the effect of PEEP on changes in intracranial pressure with the guidance of ultrasonographic measurement of the optic nerve, in patients who underwent craniotomy operation in the supine position.Material and Methods: A total of 60 patients evaluated as ASA I-II and who were scheduled for craniotomy operation in the supine position under elective conditions were included in the study. Following routine monitorization of anesthesia induction, patients were provided with 1 mcg/kg iv fentanyl, 3 mg/kg iv thiopental sodium, 0.6 mg/kg iv rocuronium. Anesthesia maintenance was then provided with 2% sevoflurane and remifentanil (0,05-2 mcg/kg/min) infusion to keep BIS between 40 and 65. Patients in Group I received a 5 cmH2O PEEP, while those in Group II received 0 cmH2O PEEP. Patients’ HR, SAP, DAP, MAP, end-tidal carbon dioxide (ETCO2), SpO2, Ppeak, Pmean, minute volume, Tv expiratory, ONSD values were measured at following time-points: T0-before anesthesia induction, T1-after the dura is opened, T2-immediately before the dura is closed, T3-before extubation.Results: There was no statistical difference in hemodynamic parameters ( SAP, DAP, MAP ) between the two groups (p>0.05). ONSD was similar between both groups at all time points except for T2 results . The mean ONSD at T2 was significantly higher in Group I (p=0.04). Ppeak and Pmean were significantly higher in Group I at all time points (p<0.05).Discussion: We investigated the effect of PEEP on the optic nerve sheath diameter and its indirect effect on intracranial pressure; we revealed that two differ-ent PEEP levels did not create a difference.
Keywords: Intracranial pressure; PEEP; Optic ultrasound
Is sternum fracture a concerning clinical situation?
Özlem Güler 1, Fatoş Kozanlı 2
1 Department of Emergency Medicine, Kahramanmaraş Sütçü İmam University Faculty of Medicine, 2 Department of Thoracic Surgery, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
DOI: 10.4328/ACAM.20461 Received: 2020-12-31 Accepted: 2021-01-14 Published Online: 2021-01-19 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):195-198
Corresponding Author: Özlem Güler, Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Department of Emergency Medicine, 46040, Onikişubat/Kahramanmaraş, Turkey. E-mail: firstname.lastname@example.org P: +90 533 413 13 25 F: +90 (344) 300 10 37 Corresponding Author ORCID ID: https://orcid.org/0000-0002-1444-7730
Aim: In this study, it was aimed to investigate the demographic characteristics of the patients diagnosed with sternum fracture (SF) admitted to our hospital in the last year, the treatments applied, and the etiological factors causing SF.Material and Methods: Fifty-six patients diagnosed with SF as a result of blunt trauma were retrospectively analyzed. Only cases with blunt trauma and SF were included in the study.Results: A total of 56 cases, 34 males (60.8%) and 22 females (39.2%), who had thoracic trauma and SF together were included in our study. In 33 (58.8%) cases, a motor vehicle accident was the mechanism with the highest rate of trauma. Rib fracture was most commonly accompanied by SFs in 28 cases (50%). The most common extra-thoracic additional organ injury was extremity fracture at various levels, which was confirmed in 13 cases (23.2%). Twelve (21%) patients with isolated SF were kept under observation in the emergency department and provided with pain relief. These patients were recommended to come for control 5 days later and were discharged. The number of cases we applied medical treatment was 50 (89.2%). There were no deaths directly related to SF.Discussion: Sternum fracture due to trauma indicates that the trauma is severe. Cases must be evaluated in terms of additional organ injury. Mortality occurs especially in patients with multiple trauma and for reasons other than thoracic. Patients with isolated non-complicated, non-displaced SF do not need hospi-talization if there are no additional organ injuries or uncontrolled pain.
Keywords: Blunt thoracic trauma; Hemothorax; Pneumothorax; Sternum fracture
Augmentation of cerclage wire strength with a basic knot technique: A biomechanical study
Ertuğrul Şahin 1, Ahmet Karakaşlı 2, Bora Uzun 3, Hasan Havıtçıoğlu 2
1 Department of Orthopaedics and Traumatology, Kemalpaşa State Hospital, 2 Department of Orthopaedics and Traumatology, Dokuz Eylul University, Faculty of Medicine, 3 Department of Biomechanics, Dokuz Eylul University, Health Science Institute, Izmir, Turkey
DOI: 10.4328/ACAM.20456 Received: 2020-12-26 Accepted: 2021-01-11 Published Online: 2021-01-15 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):191-194
Corresponding Author: Ertuğrul Şahin, Kemalpaşa State Hospital, Orthopaedics and Traumatology Clinic, 35730, Kemalpaşa, Izmir, Turkey. E-mail: email@example.com P: +90 +90 506 808 22 69 / +90 232 878 80 30 Corresponding Author ORCID ID: https://orcid.org/0000-0002-8509-3570
Aim: Loosing of cerclage wire is a common problem in the fixation of fractures and alternative techniques are required to provide more strength cable systems. The aim of this study was to evaluate the benefit of an additional knot to the cable system to increase durability and strength of wire Material and Methods: Twelve artificial bone fragments were bisected thoroughly in the coronal plane. Two mm diameter CoCr Dall Miles were used in two groups; the first group was the sleeve group (n=6) and the second group was the sleeve + knot group (n=6). All cables were once looped around the saw bone with positioning the sleeve at the beaded end of the cable, and the tensioner knob was used to create tension to 90 lb/in2 (62,05 N/cm2). In the sleeve + knot group, one more simple knot was performed with conventional surgery skill, and the two ends of cerclage wire were put into the tensioner knob to create tension again. Mechanical tension testing was performed at a velocity of 20mm/min. Axial tension force was applied until failure. The maximum force and displacement values were recorded at the failure point.Results: There was a significant difference in the mean rank of applied force between the sleeve and sleeve + knot groups (p=0,025). However, there was no statistical difference in the amount of displacement between the two groups (p=0,378). The ratio of force/displacement displayed a significant difference between the two groups, it was shown that the sleeve + knot group was more durable than the sleeve only group (p=0,01).Discussion: Adding a knot to the cable system increases the durability and strength of the cable system by approximately %40. These findings showed that adding a knot to the cable-domino system had decreased the possibility of loosening and fixation failure.
Keywords: Augmentation; Biomechanics; Cerclage wire; Dall miles; Knot; Sawbones
The correlation between knee osteoarthritis and the ABO blood group system in a Turkish population
Yüksel Uğur Yaradılmış 1, Bahtiyar Haberal 2, İsmail Demirkale 1, Murat Altay 1
1 Department of Orthopaedics and Traumatology, University of Health Sciences, Keçiören Health Practice and Research Center, 2 Department of Orthopaedics and Traumatology, Başkent University Hospital, Ankara, Turkey
DOI: 10.4328/ACAM.20337 Received: 2020-09-08 Accepted: 2020-10-22 Published Online: 2020-10-23 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):181-185
Corresponding Author: Yüksel Uğur Yaradılmış, Pınarbaşı M Afacan S No 18/12, Keçiören, 06380, Ankara, Turkey. E-mail: firstname.lastname@example.org P: +90 5327697802 Corresponding Author ORCID ID: https://orcid.org/0000-0002-7606-5690
Aim: This study aimed to determine the validity of the relationship between primary knee osteoarthritis and the ABO blood group system in the Turkish popula-tion and whether ABO group system could be a risk factor for early-onset knee osteoarthritis or revision surgery.Material and Methods: A retrospective examination of the data of 2752 patients who underwent knee arthroplasty surgery in our clinic between 2011 and 2019 was carried out. A total of 2436 primary knee osteoarthritis (PKO) patients underwent total knee arthroplasty (TKA) surgery and 206 patients underwent revision knee arthroplasty (RKA). A control group was formed of 22350 individuals aged >40 years from the same geographical region. The frequency of the ABO subgroups (A, B, O, AB) was compared between the primary knee osteoarthritis group and the control group. In addition, ABO subgroups (A, B, O, AB) were determined in the group of patients aged <65 with knee osteoarthritis (early-onset knee osteoarthritis) or revision group.Results: In the PKO group, the female to male ratio was 8:1, and the mean age was 67.2±8 years. The most significant relationship between blood groups and osteoarthritis was found in Group A (p=0.001). Group AB had a significant but low relationship (p=0.002). However, no statistically significant difference was found between age <65 years and >65 years of age (p=0.642). In comparison with the PKO group and RKA, Group A in the revision group was seen at a statistically significantly higher rate (p=0.043). Discussion: Group A blood group was found to be associated with both primary knee osteoarthritis and revision knee arthroplasty.
Keywords: Knee; Osteoarthritis; Blood group; Revision
Post-traumatic cerebral infarction (PTCI), an institutional experience
Vikas Chandra Jha, Neeraj Jha
Department of Neurosurgery , All India Institute of Medical Sciences,Patna, India
DOI: 10.4328/ACAM.20221 Received: 2020-05-26 Accepted: 2020-06-26 Published Online: 2020-08-02 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):144-149
Corresponding Author: Vikas Chandra Jha, Department of Neurosurgery , All India Institute of Medical Sciences,Patna, India. E-mail: email@example.com P: 07389831560 Corresponding Author ORCID ID: https://orcid.org/0000-0002-0080-061X
Aim: In this study, we aimed to assess effect of less studied risk factors associated with the development of post-traumatic cerebral infarction (PTCI) as severe systemic injury apart from head injury, length of stay on mechanical ventilation in ICU, sepsis, coagulopathy, DVT together with common risk factors as age, GCS severity, etc. and significance of bedside tool as TCD to detect it earlier and its implication in final clinical outcome in such cases.Material and Methods: 400 patients of head injury treated in our department between July 2018 to July 2019 were included in the study. 28 patients were diagnosed with PTCI. Risk factors for development of PTCI were analysed. Utility of TCD in early detection and clinical management of PTCI was assessed.Results: PTCI was observed in 7 % (28/400) of patients. Among risk factor analysis age (p=0.029), initial Glasgow coma scale score≤8 (p<0.028), decompres-sive craniotomy (p=0.023) and prolonged ICU stay (0.031) and TCD parameters as MCA velocity≥200cm/s (p≤0.028), PCA velocity≥70cm/s (p=0.025) were significantly associated with PTCI than without it on multivariate regression analysis. Mortality was lower in PTCI cases detected earlier (p<0.09) together with earlier clinical improvement (p<0,009) in neurological features in comparison to cases detected late.Discussion: Prolonged length of stay on a mechanical ventilator with poor GCS is a significant risk factor for the development of PTCI and early detection with a bedside tool as TCD helps in planning management better with a significant improvement in short-term mortality and clinical improvement in such cases.
Keywords: Head injury; PTCI; Risk factors; TCD; Institutional experience
Decreased annexin a2 (anxa2) levels in children with atopic dermatitis: A case-control study
Himmet Haluk Akar 1, Yakup Çağ 2, Mehmet Yaşar Özkars 3, Mikdat Yıldız 4
1 Department of Pediatric Immunology and Allergy, University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, 2 Department of Pediatrics, University of Health Sciences Kartal Dr. Lütfi Kırdar Training and Research Hospital, Istanbul, 3 Department of Pediatric Immunology and Allergy, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, 4 Department of Pediatrics, Batman Maternity and Child Health Hospital, Batman, Turkey
DOI: 10.4328/ACAM.20236 Received: 2020-06-09 Accepted: 2020-07-11 Published Online: 2020-07-19 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):172-175
Corresponding Author: Himmet Haluk Akar, İstanbul Health Sciences University, Kanuni Sultan Süleyman Training and Research Hospital, Department of Pediatric Immunology and Allergy, İstanbul, Turkey. E-mail: firstname.lastname@example.org GSM: +90 532 516 67 84 Corresponding Author ORCID ID: https://orcid.org/0000-0002-7266-5445
Aim: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in children. The pathogenesis of AD has not been clearly understood. The role of annexin A2 (ANXA2), which is an anti-inflammatory mediator, has not been investigated in the pediatric population with AD. The aim of this study is to investigate serum ANXA2 levels in children with AD. Material and Methods: Three groups were enrolled in this study; an SPT-Pos group (skin prick test positive 25 subjects with AD), an SPT-Neg group (skin prick test negative 25 subjects with AD), and a control group (27 healthy subjects). The serum ANXA2 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: We observed significantly lower serum ANXA2 levels in the disease group than in the control group [0.53 (range 0.14 – 4.38) pg/mL vs 0.94 (range 0.40 – 8.74) pg/mL, respectively; p = 0.01], especially in the SPT-Post group. However, there was no correlation among the parameters of ANXA2, IgE, eosinophil counts. Discussion: ANXA2 may have the role of an anti-inflammatory mediator in the pathogenesis of AD in children. The ANXA2-associated pathways may be con-sidered in the development of novel therapeutic approaches for the treatment of patients with AD.
Keywords: Annexin A2; Atopic Dermatitis; Children
The use of ultrasonography in traumatic muscle lesions: A practical first-line imaging tool
Hasanali Durmaz¹, Mehmet Ercüment Döğen², Ümit Yaşar Ayaz², Erdem Birgi¹
¹Department of Radiology,University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, ²Department of Radiology, Mersin City Training and Research Hospital, Mersin, Turkey
DOI: 10.4328/ACAM.20239 Received: 2020-06-08 Accepted: 2020-07-11 Published Online: 2020-07-19 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):176-180
Corresponding Author: Hasanali Durmaz, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Radiology, Ankara, Turkey. E-mail: email@example.com GSM: +90 538 279 79 07 Corresponding Author ORCID ID: https://orcid.org/0000-0003-3230-9240
Aim: In this study, we aimed to evaluate traumatic muscle lesions and trauma-related gross intramuscular hemorrhages using ultrasonography (US). Material and Methods: This retrospective study included 32 cases (23 males, 9 females) with a history of muscle trauma that underwent US. The mean age was 24.3 years. Static and dynamic US and color Doppler US were performed in axial and longitudinal planes. Patients were divided into two groups as penetrating and non-penetrating (blunt) muscle trauma. The absence of intramuscular hematoma/fluid and muscle fibers was accepted as the criteria of muscle rupture in both trauma types. Non-penetrating traumas were also divided into intrinsic and extrinsic. Intrinsic muscle injuries were graded as mild, moderate, and severe.Results: Among the cases, 78.1% (n=25/32) developed as a result of non-penetrating trauma and 21.9% (n=7/32) cases as a result of penetrating trauma. Approximately 2/3 (64%) of non-penetrating muscle traumas (n=25/32) were intrinsic and 1/3 (36%) were extrinsic. In all cases, including unilateral muscle lesions such as collection/mass appearances compatible with hemorrhage-hematoma of various sizes and ages were demonstrated in gluteus maximus (25%), quadriceps femoris (18.7%), sternocleidomastoid (18.7%), rectus abdominis (15.6%), hamstring (9.4%), biceps brachii (6.3%) and gastrocnemius (6.3%). No vascularization in hemorrhage-hematoma was detected with Doppler US in any patient. Discontinuity in traumatized muscle fibers was present in all cases. Intrinsic muscle injury was classified as mild-grade 1 (12.5%), moderate-grade 2 (75%), and severe-grade 3 (12.5%) under ultrasonography.Discussion: Ultrasonography is a practical and effective imaging method in the diagnosis of traumatic muscle lesions.
Keywords: Ultrasonography; Muscles; Injuries
The effect of a home exercise program prescribed by physiotherapists for pain relief
Muhammed Arca 1, Elif Dilara Durmaz 1, Omer Satıcı 2, Ayse Ferdane Oguzoncul 3
1 Physical therapy and rehabilitation, Saglik Bilimleri University, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakır, 2 Department of Biostatistics, Dicle University, Medical Faculty, Diyarbakır, 3 Department of Public Health, Firat University, Medical Faculty, Elazig, Turkey
DOI: 10.4328/ACAM.20232 Received: 2020-06-04 Accepted: 2020-07-12 Published Online: 2020-07-19 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):167-171
Corresponding Author: Ayse Ferdane Oguzoncul, Department of Public Health, Firat University, Medical Faculty, Elazig, Turkey. E-mail: firstname.lastname@example.org GSM: +90 5324839830 P: 0090424 2370000-4685 Corresponding Author ORCID ID: https://orcid.org/0000-0002-9820-9720
Aim: The aim of this study was to evaluate the effect of the home exercise program on the pain of physiotherapy and rehabilitation outpatients.Material and Method: The study included 316 patients with low back, neck, shoulder, and knee pain aged 18-65 years. A personal information form was filled out to obtain demographic information about these patients. After exercise training given by the physiotherapists, the pain of the patients was evaluated by a visual analog scale (VAS). After 4 weeks, the patients were called by telephone and questioned whether they were doing the exercises and their pain severity.Results: Among patients, 54,4% (172) were female; 72,8% of the patients with a mean age of 39.85±13.77 years were married, 40,8% were primary school graduates and 37,3% were housewives. One hundred three patients applied (32,6%) with neck pain, 132 (41,8%) with low back pain, 29 (9,2%) with shoulder pain and 52 (16,5%) with knee pain. It was observed that 55.4% (175) of the patients who were prescribed training did not perform their exercises. Among patients who exercised, 69,6% did not use analgesics in this process. A statistically significant result was found when the before and after exercise VAS data of participants who did exercise and those who did not were compared (p=0.001).Discussion: In the study by Kılıç, more than half of the patients who exercised benefited from the exercises they performed and stated that the exercise de-creased problems such as pain, locking, fatigue, and limitation of movement due to disease. It was determined that the patients who completed the exercise program had less pain. Regular exercise programs will lead to positive outcomes.
Keywords: Pain; Low back; Neck; Exercise
Retrospective analysis of smoking cessation campaign in aviation personnel
Erdinc Ercan 1, Pelin Ercan 2
1 Department of Aerospace Medicine, Health Science University, 2 Primary Health Care Center, Main Jet Base, Turkish Air Force, Eskisehir, Turkey
DOI: 10.4328/ACAM.20228 Received: 2020-05-28 Accepted: 2020-06-28 Published Online: 2020-07-09 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):157-161
Corresponding Author: Erdinc Ercan, Yunus Emre State Hospital, 2 Eylul Building, Hyperbaric Oxygen Therapy Clinic, Eskisehir, Turkey. E-mail: email@example.com P: +90 541 367 7976 Corresponding Author ORCID ID: https://orcid.org/0000-0002-4478-7031
Aim: Because of many health hazards, we carry out training and treatment efforts to reduce the use of tobacco products by aviation personnel. In this retro-spective study, we aimed to evaluate our smoking cessation rates according to treatment modality, patients’ education level, and marital status via outpatient clinic records. Material and Methods: The records of the Smoking Cessation Policlinic between January 01, 2016 and April 30, 2018 were analyzed in this study. Patients’ demographics, smoking attitudes, cessation method, the Fagerström Test for Nicotine Dependence (FTND), anxiety and depression scales were evaluated. The Kolmogorov-Smirnov normality test, Independent Samples T-Test or the Mann-Whitney-U test were used in between-groups analyzes. The Chi-Squared test was used for testing relationship between categorical variables.Results: One hundred forty-two patients were included in this study and 3 of them were female. All females and 38.9% of males quit smoking. The overall cessation rate was 40.1%. The duration of smoking was higher, the first and last measured CO values were lower, and the follow-up periods were longer in the quitters’ group (p<0.05). The cigarettes smoked per day and FTND scores were higher in the non-quitters’ group (p>0.05). The cessation rate was slightly increased with education duration (p>0.05). Married patients’ cessation rate was higher than single or separated patients (p>0.05). The highest cessation rate was achieved in the Varenicline group (p<0.001).Discussion: The use of tobacco products in aviation personnel is similar to that of the normal population. We can suggest that cessation success can be af-fected by marital status, addiction level, education, and the treatment method.
Keywords: Smoking Cessation; Fagerström test; Nicotine addiction; Aviation personnel
Etiology and prevalence of hyponatremia in geriatric patients with fragility hip fractures
Emine Emektar, Seda Dagar, Hüseyin Uzunosmanoğlu, Fatmanur Karaaslan, Şeref Kerem Çorbacıoğlu, Yunsur Çevik
Department of Emergency Medicine, Keçiören Training and Research Hospital, Ankara, Turkey
DOI: 10.4328/ACAM.20229 Received: 2020-06-01 Accepted: 2020-07-01 Published Online: 2020-07-09 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):162-166
Corresponding Author: Emine Emektar, Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Street No:25, 06280, Keçiören, Ankara, Turkey. E-mail: firstname.lastname@example.org P: +90 5055562675 Corresponding Author ORCID ID: https://orcid.org/0000-0002-6056-4401
Aim: In this study, we aimed to determine the prevalence and etiological factors of hyponatremia among geriatric patients, who presented to the emergency department (ED) with simple mechanical falls and were diagnosed with a hip fragility fracture, and to compare these patients’ clinical course with that of patients with a normal serum sodium level. Material and Method: This study is a retrospective study. Patients aged 65 years or older, admitted to the ED with hip fragility fracture, were enrolled in the study. The patients’ serum sodium level at admission was evaluated. Study data were analyzed with IBM SPSS 20.0 (Chicago, IL, USA) /statistical software. Results: This study enrolled 646 patients; 30.5 % of the patients were male and the median age was 85 (IQR 25-75, 78-89) years. Hyponatremia was present in 16.4% (n=106) of the patients. A comparison of the normonatremic and hyponatremic patients showed that the hyponatremic ones had a greater prevalence of osteoporosis, proton pump inhibitor (PPI), and diuretic use, a higher creatinine level, and a lower hematocrit level (p=0.002, p=0.042, p=0.008, p=0.023, p=0.001, respectively).Discussion: Hip fractures are emergency conditions associated with high mortality, which are especially common in the elderly. We showed a considerable prevalence of hyponatremia in geriatric hip fractures. We believe that mild chronic hyponatremia is one of the important risk factors for fragility hip fracture. The majority of hyponatremia cases are the result of comorbidities and polypharmacy.
Keywords: Fragility fracture; Hyponatremia; Geriatric
The efficiency of deep learning for the diagnosis of psammomatous meningioma
Syed Usama Khalid Bukhari 1, Asmara Syed 3, Syed Khuzaima Arslan Bokhari 2, Syed Sajid Hussain Shah 3
1 Department of Computer Science, The University of Lahore, Islamabad, Pakistan, 2 Pediatric medicine, Doctors hospital, Lahore, Pakistan, 3 Faculty of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia
DOI: 10.4328/ACAM.20226 Received: 2020-05-27 Accepted: 2020-06-26 Published Online: 2020-07-05 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):153-156
Corresponding Author: Syed Usama Khalid Bukhari, Department of Computer Science, The University of Lahore, Islamabad, Pakistan. E-mail: email@example.com P: +92 349 1050 449 Corresponding Author ORCID ID: https://orcid.org/0000-0003-1581-8609
Aim: The study aims to assess the efficiency of deep machine learning (convolutional neural network architecture) for the diagnosis of psammomatous menin-gioma by evaluating the digital pathology images.Materials and Methods: A total of three hundred and twenty (320) digital images have been acquired from the anonymized hematoxylin and eosin-stained slides, which included 161 images of Psammomatous Meningioma and 159 images of normal intracranial tissue. The dataset was divided into a train set, 80% of the entire data, and 20% into the test data set. ResNet-18 architecture (state of the art deep learning computer vision algorithms) is used to diagnose these cases.Results: A total of 161 images of psammomatous meningioma and 159 images of normal tissue are used; 80% of the collected data was used for training, where 20% for testing purposes. Using deep learning, we achieved 98.79 F1-Score and 98.4% accuracy. Discussion: The advancement in the field of artificial intelligence has opened a lot of new channels and generated new opportunities to develop computer-aided diagnostic systems. The applications of machine learning have revealed promising results for the histopathological evaluation of neoplastic lesions. In the present study, the excellent diagnostic accuracy (98.4 %) has been achieved with the convolutional neural network architecture. There was an F1-score of 98.79 for the diagnosis of psammomatous meningioma in the present series. The studies conducted for the diagnosis of breast cancer metastasis, lung carcinoma, prostatic malignant tumors, and basal cell carcinoma also revealed excellent results. Convolutional neural network (CNN) architecture is emerging as a quite efficient deep machine learning tool for the analysis of the pathology images. This technology may be quite a valuable adjunct tool in diagnostic surgical pathology.
Keywords: Psammomatous meningioma; Histopathological diagnosis; Deep learning
Initial serum lactate levels of COVID-19 patients
Sadiye Yolcu 1, Kemal Sener 1, Nurettin Yılmaz 1, Mehmet Tunç 1, Ahmet Aktas 2, Nurettin O. Dogan 3
1 Department of Emergency Medicine, Adana City Research & Education Hospital, Adana, 2 Department of Internal Medicine, Cumhuriyet University Medical School, Sivas, 3 Department of Emergency Medicine, Kocaeli University Medical School, Kocaeli, Turkey
DOI: 10.4328/ACAM.20225 Received: 2020-05-28 Accepted: 2020-06-26 Published Online: 2020-07-04 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):150-152
Corresponding Author: Sadiye Yolcu, Department of Emergency Medicine, Adana City Research & Education Hospital, Adana, Turkey. E-mail: firstname.lastname@example.org GSM: +90 5053596731 Corresponding Author ORCID ID: https://orcid.org/0000-0003-3323-9213
Aim: In this study, we aimed to research whether the serum lactate of the COVID-19 patients presented to the initial emergency department can be used to make prognosis of the patients. Materials and Methods: A total of 39 COVID-19 patients were included in the study. Fourteen (35.8%) patients were over 65 years old (Group 1). Twenty-five patients (64.2%) were under 65 years old (Group 2). The diagnosis was made via the oro-nasopharyngeal swab PCR test. We noted the demographic data (age, gender, comorbidities), initial (emergency service presentation) complete blood count parameters including WBC, Plt/Lymp ratio, CRP, procalcitonin and serum lactate levels. We also noted the hospitalization unit (clinic/intensive care unit), hospitalization length, and the outcomes. Patients were divided into two groups according to 65 years and the groups’ laboratory results with the prognosis. Results: The mean age of the study group was 55 years. Fourteen (35.8%) patients were over 65 years old. Serum lactate levels did not significantly differ between groups. Hospital length of stay was significantly longer in patients over 65 years of age. Age and hospitalization length were positively correlated with age in all patients.Discussion: Serum lactate level measurement has recently become an important parameter especially for critically ill patients. It is beneficial for predicting the severity and prognosis in severe infections. Serum lactate levels in COVID-19 patients did not differ between age groups. Hospitalization length was longer in elderly patients.
Keywords: COVID-19; Lactate; Prognosis
The relation between hyponatremia at presentation, severity of disease and length of stay in patients with bronchiolitis
Fatih Isleyen, Mehmet Tekin, Capan Konca
Department of Pediatrics, Adiyaman University, School of Medicine, Adiyaman, Turkey
DOI: 10.4328/ACAM.20211 Received: 2020-05-15 Accepted: 2020-06-15 Published Online: 2020-06-30 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):129-133
Corresponding Author: Mehmet Tekin, Adiyaman University, School of Medicine, Department of Pediatrics, Kahta Street, 02000 Adiyaman, Turkey. E-mail: email@example.com GSM: +90 532 7699846 F: + 90 416 2252660 Corresponding Author ORCID ID: https://orcid.org/0000-0002-1157-1314
Aim: In this study, we aimed to investigate the relationship between hyponatremia at presentation and severity of disease and length of stay in children admit-ted to hospital with acute bronchiolitis.Material and Methods: This cross-sectional study was performed at a tertiary care hospital between May 2017 and April 2018. One hundred seventy children aged 1-24 months admitted with a diagnosis of acute bronchiolitis were included in the study. Demographic and biochemical data were recorded together with data associated with clinical course and length of stay.Results: Hyponatremia was present in 62 (36.4%) of the 170 patients. Thirteen patients (20.9%) in the hyponatremic group were diagnosed with moderate bronchiolitis and 17 (27.5%) with severe bronchiolitis, while in the normonatremic group, 14 (12.9%) with moderate bronchiolitis and 9 (8.4%) with severe bronchiolitis (p<0.001). High-flow nasal cannula (FNC) requirement was present in 17 patients in the hyponatremic group and 17 in the normonatremic group (p=0.001). The risk of development of severe bronchiolitis increased 0.085-fold in patients with hyponatremia. The median length of hospitalization was 5 (2-21) days in the hyponatremic group and 4 (2-11) days in the normonatremic group (p=0.001). Hyponatremia increased length of stay approximately 4.7-fold. Discussion: The risk of developing severe bronchiolitis and non-invasive mechanical ventilation requirements was significantly higher in the hyponatremic group. The length of hospital stay was greater in cases of bronchiolitis with hyponatremia. We think that measuring sodium levels during hospitalization in cases of bronchiolitis will be useful in predicting the risk of development of severe bronchiolitis and extended length of stay.
Keywords: Bronchiolitis; Hyponatremia; Infant; Length of stay
Comparison of primer and revisional laparoscopic mini-gastric bypass (MGB) for failed restrictive procedures: 2-year results at a tertiary center
Fahrettin Acar, Bayram Çolak, Mustafa Şahin
Department of Surgery, Faculty of Medicine,Selcuk University, Konya, Turkey
DOI: 10.4328/ACAM.20210 Received: 2020-05-14 Accepted: 2020-06-15 Published Online: 2020-06-30 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):124-128
Corresponding Author: Fahrettin Acar, Department of General Surgery, Selcuk University, Faculty of Medicine, Campus of Alaaddin Keykubat, 42075, Selcuklu, Konya, Turkey. E-mail: firstname.lastname@example.org GSM: +90 533 9638946 P: +90 332-241-5000 int-44709 Corresponding Author ORCID ID: https://orcid.org/0000-0003-1797-1770
Aim: Revisional surgery is becoming a common and challenging practice in bariatric centers. The aim of this study was to evaluate laparoscopic mini-gastric bypass (MGB) as a revisional procedure for failed restrictive bariatric procedures.Material and Methods: One hundred sixty patients who underwent MGB between April 2012 and December 2017 were included in this retrospective study. Revisional MGB was defined as rMGB performed after failure of a first restrictive procedure. The main outcome measures were the success of therapeutic strategies, morbidity, body mass index (BMI), and percentage of excess BMI loss (%EBMIL) before and after revision.Results: Forty patients (25%) who had prior restrictive bariatric surgery (including 26 laparoscopic sleeve gastrectomies, 9 gastric plications, and 5 adjustable gastric bandings) underwent conversion to rMGB. Ninety patients (75%) underwent primary MGB (pMGB group). Both groups were comparable in age, gender, BMI, and preoperative co-morbidities. The pre-operative mean BMI of the rMGB group was 45.5 ± 7 kg/m2. No increase in morbidity was found between the 2 groups. Two patients with pMGB and one patient required conversion to RYGB after rMGB because of intractable biliary reflux. At 2 years, mean BMI was 30.5 kg/m2 and mean %EBMIL was 72% after rMGB; no significant differences were found compared with pMGB (BMI =29.5 kg/m2, %EBMIL =73%). Co-morbidities and remission rates were statically similar.Discussion: The results of our study show that rMGB is a safe and effective revisional procedure after failed restrictive bariatric surgery compared with pMGB.
Keywords: Bariatric surgery; Revision; Mini-Gastric bypass; Sleeve gastrectomy; Gastric plication
Evaluation of protective effect of L-carnitine and N-acetylcysteine in mesenteric ischemia-reperfusion injury model in rats
Utku Murat Kalafat 1, Busra Bildik 1, Serkan Dogan 1, Rabia Birsen Tapkan 1, Melis Dorter 1, Ayse Fethiye Basa Kalafat 1, Bahaeddin Tapkan 2, Said Incir 3, Basar Cander 1
1 Department of Emergency Medicine, Kanuni Sultan Suleyman Training and Research Hospital, University of Health Science, 2 Department of General Surgery, İstanbul Training and Research Hospital, 3 Department of Biochemistry, Koc University, Medical Faculty, Istanbul, Turkey
DOI: 10.4328/ACAM.20212 Received: 2020-05-17 Accepted: 2020-06-27 Published Online: 2020-06-30 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):134-138
Corresponding Author: Busra Bildik, Atakent Mh. Turgut Ozal Cd. No:1 Altinsehir/Kucukcekmece, 34303, Istanbul, Turkey. E-mail: email@example.com P: +90 532 605 47 36 Corresponding Author ORCID ID: https://orcid.org/0000-0002-1546-4612
Aim: Ischemia-reperfusion injury is an important dilemma in surgical modalities. The mechanism of IR damage is related to oxidative stress mediators. L-carnitine and N-acetylcysteine are thought to have antioxidant activity. In our study, we aimed to evaluate the effects of short-term administration of these two drugs and to compare their effects on oxidative stress parameters in the experimental mesenteric ischemia-reperfusion model in rats. Materials and Methods: Twenty-four female Sprague-Dawley rats were allocated into 3 experimental groups. In Group 1 (CG) (n=8), rats underwent occlusion of the superior mesenteric artery for 30 minutes and were not given any medications. In Group 2 (NG) and Group 3 (LG), rats underwent occlusion as CG. Rats were given 150 mg/kg (IP) N-acetylcysteine and 300 mg/kg IP L-carnitine according to their groups 15 minutes before reperfusion. Rats were sacrificed with high dose anesthetic drugs after 60 minutes of reperfusion. Blood and liver tissue samples were obtained to investigate total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Results: By biochemical examination, all groups showed similar levels of TOS. There was no statistically significant difference between the level of TAS and OSI in all groups (p>0,05). There was no any statistically significant difference between the groups for TAS measurements (p=0.061; p>0.05); however, higher measurement values in the L-Carnitine group is considerable.Discussion: Although the use of drugs with proven antioxidant efficiency after ischemia may cause a histologically significant difference in IR injury, there was no significant efficiency in the reduction of superoxides in the circulation. Therefore, we believe that the use of NAC and L-carnitine as antioxidants after the development of ischemia does not help to prevent intestinal IR injury.
Keywords: Ischemia, L-carnitine, Mesenteric, N-acetylcysteine
The Efficiency of Colistin, Minocycline, Tigecycline and Doxycycline against multidrug-resistant Acinetobacter strains
Selim Gorgun 1, Murat Guzel 2, Ozgur Gunal 3, S. Sırrı Kılıc 3
1 Department of Microbiology and Clinical Microbiology Laboratory, Training and Research Hospital, Health Sciences University, 2 Department of Emergency Medicine, Training and Research Hospital, Health Sciences University, 3 Department of Infectious Diseases and Clinical Microbiology, Training and Research Hospital, Health Sciences University Samsun, Turkey
DOI: 10.4328/ACAM.20207 Received: 2020-05-20 Accepted: 2020-06-20 Published Online: 2020-06-30 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):120-123
Corresponding Author: Selim Gorgun, Department of Microbiology and Clinical Microbiology Laboratory, Training and Research Hospital, Health Sciences University, Ilkadım, 55090, Samsun, Turkey. E-mail: firstname.lastname@example.org P: +90 5366168844 F: +90 3622778569 Corresponding Author ORCID ID: https://orcid.org/0000-0001-5841-591X
Aim: In recent years, it has been emphasized that antibiotics less used in the past may be an alternative for the treatment of infections caused by multidrug-resistance (MDR) Acinetobacter strains. In this study, we aimed to determine the effectiveness of colistin, tigecycline, minocycline, and doxycycline against MDR Acinetobacter strains. Material and Methods: The study was carried out in Samsun Training and Research Hospital in 2018. MDR Acinetobacter spp. obtained from 68 patients and reproduced in various clinical samples. Vitec 2 system (BioMerieux, France) was used for the identification of strains and susceptibility testing. The sensitivity of minocycline, tigecycline, and doxycycline was studied in Mueller Hinton agar by Kirby Bauer disc diffusion method. Colistin resistant strains were studied using tube dilution method and minimal inhibitory concentration (MIC) values were determined. Results: MDR Acinetobacter strains were mostly isolated from cultures from tracheal aspirate (32.4%) and wound samples (31.5%). The sensitivity of MDR Acinetobacter strains to colistin, tigecycline, doxycycline, and minocycline were 82.4%, 41.2%, 23.5%, 8.8%, respectively. Discussion: We consider that the sensitivity to colistin is high in MDR Acinetobacter spp. infections and that combination of antibiotics, which were used in the past but became less-used later, and other antibiotics can be used for the treatment.
Keywords: MDR Acinetobacter spp; Tigecycline; Colistin; Minocycline; Doxycycline
The efficiency of Polytendon Complex (PC) and St. John’s Wort oil (Hypericum perforatum) on healthy Achilles tendon in rats
Kutsi Tuncer 1, 2, Mehmet Demir 1, Eyüp Şenocak 3, Ali Sefa Mendil 4, Arzu Gezer 5, Basri Pür 1, Recep Öztürk 6
1 Department of Orthopaedic and Traumatology, Medical Faculty, Ataturk University, Erzurum, 2 Anesthesiology Clinical Research Office, Ataturk University, Erzurum, 3 Clinic of Orthopaedic and Traumatology, Regional Education Research Hospital, Erzurum, 4 Department of Pathology, Veterinary Medicine Faculty, Erciyes University, Kayseri, 5 Department of Histology, Vocational School of Health Services, Ataturk University, Erzurum, 6 Department of Orthopaedic and Traumatology, Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
DOI: 10.4328/ACAM.20213 Received: 2020-05-18 Accepted: 2020-06-12 Published Online: 2020-06-24 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):139-143
Corresponding Author: Recep Öztürk, Dr Abdurrahman Yurtaslan Ankara Oncology Training And Research Hospital, Demetevler Mahallesi, Vatan Cad., 06200 Yenimahalle/Ankara, Turkey. E-mail: email@example.com GSM: +90 5054634794 F: +90 312 334 03 52 Corresponding Author ORCID ID: https://orcid.org/0000-0002-6753-9321
Aim: This experimental animal study aimed to investigate the effects of Tendoflex® (a polytendon complex) and St. John’s wort oil (Hypericum perforatum) on healthy Achilles tendons in rats.Material and Method: Twenty Wistar albino rats weighing 250-350 g were randomly allocated into four groups. In Group A, Tendoflex® capsule per 2.5 kg/day was administered orally via gavage. In Group B, Hypericum perforatum 300mg/kg/day was given orally via gavage. In Group C, Tendoflex® and Hypericum perforatum were given orally via gavage at the doses mentioned above. In Group D, no intervention was done to the control group. After four weeks, all rats were sacrificed and biomechanical tests of the Achilles tendon and histological examinations were performed.Results: Histological results revealed a significant difference between the groups regarding Type-1 and Type-3 immunopositivity in the Achilles tendon tissues (p <0.05). Immune-positivity values were high in group B, moderate in group C, mild in group A and insignificant in group D. The highest top tendon strengths in the biomechanical tests were recorded in the Hypericum perforatum and mix groups at the fourth week (83.75±16.1N and 81.875±9.7 N, respectively) followed by the Tendoflex® group (66.875±7.5 N). On the other hand, the lowest tendon strengths were obtained in the control group (54.375±7.1N).Discussion: Tendoflex® and Hypericum perforatum increased the Achilles tendon tensile strength in rats. This result may be related to the fact that Type-1 and Type-3 collagen immunity was higher in all groups compared to the control group. Tendoflex® and Hypericum perforatum can be used to prevent tendon rupture or to avoid re-rupture in patients undergoing tendon repair.
Keywords: Achilles Tendon; Tendoflex; Hypericum perforatum; Prophylaxis
Renal leiomyosarcoma: A rare entity
Arzu Erdem Taşdemir, İpek Özer, Hatice Karaman
Department of Pathology, Kayseri City Training and Research Hospital, Kayseri, Turkey
DOI: 10.4328/ACAM.20263 Received: 2020-06-30 Accepted: 2020-12-23 Published Online: 2021-01-05 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):212-215
Corresponding Author: Arzu Erdem Taşdemir, Department of Pathology, Kayseri City Training and Research Hospital, Kayseri, Turkey. E-mail: firstname.lastname@example.org P: +90 5327423680 Corresponding Author ORCID ID: https://orcid.org/0000000251836663
Renal leiomyosarcoma is one of the rare tumors. It constitutes only 0.5% of all primary renal malignancies. It accounts for 50-60% of primary renal sarcomas. The majority of cases are adults, and their mean age is 58 years. Renal leiomyosarcomas originate from the renal capsule, pelvis renalis, calyces, and vascular smooth muscles. These tumors have a poor prognosis, and surgery is the main treatment modality. In this article, in the light of the literature, we aimed to pres-ent a case report of renal leiomyosarcoma 16x15x11cm in size in the right kidney of a 39-year-old female patient who presented with complaints of abdominal pain and hematuria. Although leiomyosarcomas are limited in the kidney, they are aggressive tumors with a poor prognosis.
Keywords: Leiomyosarcoma; Kidney; Aggressive tumors
A Treatment arising from tradition: A Report of indigo blue therapy for granulomatous mastitis
Department of General Surgery, Acibadem Mehmet Ali Aydinlar University Atakent Hospital, Istanbul, Turkey
DOI: 10.4328/ACAM.20355 Received: 2020-09-27 Accepted: 2020-10-29 Published Online: 2020-11-09 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):219-221
Corresponding Author: Selim Keçeoğlu, Department of General Surgery, Acibadem Mehmet Ali Aydinlar University Atakent Hospital, Istanbul, Turkey. E-mail: email@example.com P: +90 5307892685 Corresponding Author ORCID ID: https://orcid.org/0000-0002-9985-3972
The indigo plant is used globally for its blue dye, and plant-based indigo dyeing has been traditionally practiced for centuries in a broad geographic area. In addition to this purpose, indigo is used medically in many African tribal areas for its anti-inflammatory and anti-microbial effects. This article presents a case of granulomatous mastitis that was treated by a tribal healer with indigo blue, which provided temporary relief of symptoms for one year until secondary bac-terial infection occurred. Some studies reported that indigo blue provides symptomatic relief related to its anti-oxidant, anti-microbial and anti-inflammatory mechanisms, which could be helpful in autoimmune diseases such as granulomatous mastitis. We strongly believe that this patient’s results warrant further investigation of indigo blue’s effect on granulomatous mastitis.
Keywords: Indigo blue; Granulomatous mastitis; Indigofera
Teratoma of the greater omentum: An extremely rare case report
Oğuzhan Özdemir 1, Turgut Anuk 2, Volkan Kızılgöz 1, Hasan Çantay 2
1 Department of Radiology, Kafkas University, Faculty of Medicine, 2 Department of General Surgery, Kafkas University, Faculty of Medicine, Kars, Turkey
DOI: 10.4328/ACAM.20350 Received: 2020-09-22 Accepted: 2020-10-22 Published Online: 2020-10-27 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):216-218
Corresponding Author: Volkan Kızılgöz, Kafkas University, Faculty of Medicine, Department of Radiology, Kars, Turkey. E-mail: firstname.lastname@example.org P: +90 5057994013 Corresponding Author ORCID ID: https://orcid.org/0000-0003-3450-711X
Although mature cystic teratomas or dermoid cysts are common ovarian tumors, the extragonadal site is extremely low. The most common extragonadal site to find these tumors is the greater omentum. Reports reveal that only 32 cases of teratoma of the greater omentum have been published to date. We report an extremely rare case of mature cystic teratoma of the omentum in a 51-year-old woman who presented with nonspecific lower abdominal pain. After imaging with contrast-enhanced abdominal CT, the patient underwent cystectomy for the omental teratoma.
Keywords: Teratoma; Dermoid; Omentum; Omental teratoma; Computed tomography
Serial casting for equinus deformity in children with cerebral palsy: A systematic review
Mohammed M. El Sayeh 1, Samia A. Abdel Rahman 2, Ihab M. Abd El Kafy 2, Mahmoud S. El Fakharany 2
1 Physical therapist at El Santa General Hospital, Ministry of Health, 2 Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Cairo, Egypt
DOI: 10.4328/ACAM.20264 Received: 2020-06-27 Accepted: 2020-09-04 Published Online: 2020-10-28 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):222-227
Corresponding Author: Mahmoud S. El Fakharany, Department of Physical Therapy for Pediatrics , Faculty of Physical Therapy, Cairo University, Cairo, Egypt. E-mail: Mahmoud.email@example.com P: 01067904792 Corresponding Author ORCID ID: https://orcid.org/0000-0002-3943-4469
Aim: The primary cause of gait deformity in children with cerebral palsy (CP) is equinus foot. Children with equinus foot typically receive physiotherapy as part of their care, as serial casting. In this study, we aimed to systematically examine the impact of serial casting procedure in children with CP with equinus deformity.Material and Methods: Articles were identified from 2008 to 2019 by literature searches using Medline (MEDLINE), physiotherapy evidence base (PEDro), and Cochrane database. Randomized trials focused on CP children with equinus deformity were included. Data were extracted from the included studies and methodological quality of these data was evaluated using the PEDro scale. The modified Sackett scale was used to evaluate the level of evidence of each intervention.Results: Four trials with good quality methodology were identified with good quality methodology. It was examined whether studies regarding intervention techniques were heterogeneous or not. Findings were analyzed in qualitative terms.This review revealed moderate evidence in three articles about the effec-tiveness of serial casting application and the ineffectiveness in one article, in addition to traditional physiotherapy programs. Meta-analysis was applied for homogeneous studies and it showed that serial casting could be used as a method to improve deformity of the equinus.Discussion: The current systematic review analyzed four randomized controlled trials, applying strict inclusion selection criteria. The present evidence supports the use of serial casting for improving equinus deformity and modulates spasticity in children with CP and it is considered a moderate evidence of the efficacy of serial casting application.Although the findings of this review support the effectiveness of serial casing application in CP children with equinus deformity, additional randomized control trials with a larger sample size are still required to confirm the present evidence.
Keywords: Serial casting; Deformity of equinus; Cerebral palsy; Toxin of botulinum; Abnormality of gait; Scissoring
Therapeutic approaches for COVID 19: Challenges and successes
Rim M. Harfouch 1, Samer Alshaikh 2, Mohammad Alshimaly 3, Amany Assaad 3, Jehan Ahmad 3, Haya Zoughaibi 2, Maher Hammadi 3, Yahya Elshimali 4
1 Faculty of pharmacy, Al Sham private university, Latakia, Syria, 2 Faculty of medicine, Tartous university, Tartous, Syria, 3 Faculty of pharmacy, Tartous university, Tartous, Syria, 4 Faculty of medicine, Charles Drew University for Medicine and Science/University of California Los Angeles (UCLA), USA
DOI: 10.4328/ACAM.20270 Received: 2020-07-02 Accepted: 2020-08-11 Published Online: 2020-08-16 Printed: 2021-02-01 Ann Clin Anal Med 2021;12(2):228-233
Corresponding Author: Rim Harfouch, Department of microbiology and biochemistry, Faculty of pharmacy, Al Sham private university, Latakia, Syria 00000 E-mail: firstname.lastname@example.org P: 00963932292303 Corresponding Author ORCID ID: https://orcid.org/0000-0001-7002-8728
The novel coronavirus SARS-COV-2 or COVID-19 was first discovered in Wuhan, China in late December 2019 and soon became a global pandemic. The virus causes flu- like symptoms and is potentially lethal. The rapid spread of the virus leaves the world in total paralysis and has devastating effects on the health, economic, and social levels of most countries.No treatment has been approved yet and the world really needs a precise and urgent medication. Certainly, the developing of a new specific drug for COVID-19 would take a longer time than expected but it is hoped that this task will be completed sooner than later; therefore recent studies have prioritized testing previously FDA-approved drugs for other indications and whether they have significant effects on COVID-19 or not. In this study, we discuss recent applications, protocols, and the outcomes of these drugs as advised by healthcare institutions and providers, as well as to conduct a literature review.
Keywords: COVID-19; Available treatments; Practical approach