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Original Article

The roles of vitamin B12, 25(OH)D, and folate in primary nocturnal enuresis: A single center experience

Ahmet Keleş 1, Ahmet Karakeçi 2, Rahmi Onur 3

1 Department of Urology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, 2 Department of Urology, Faculty of Medicine, Fırat University, Elazığ, 3 Department of Urology, Faculty of Medicine, Marmara University, Istanbul, Turkey

DOI: 10.4328/ACAM.22020 Received: 2023-10-22 Accepted: 2024-01-08 Published Online: 2024-02-14

Corresponding Author: Ahmet Keleş, Department of Urology, Faculty of Medicine, Istanbul Medeniyet University, Prof. Dr. Süleyman Yalçın City Hospital, Fahrettin Kerim Gökay Caddesi, 34720, Istanbul, Turkey. E-mail: drkeles2009@yahoo.com P: +90 505 395 49 37

Corresponding Author ORCID ID: https://orcid.org/0000-0001-5436-1803

This study was approved by the Ethics Committee of Fırat University Faculty of Medicine (Date: 2020-11-12, No: 97132852/050.01.04/)

Evaluation of serum vitamin D levels in pregnant women with gestational diabetes mellitus

Narin Ece Çakmak1, Burak Çakmak1, Gül Özel Doğan1, Alev Atış Aydın2

1 Department of Obstetrics and Gynecology, 2 Department of Perinatology, Şişli Hamidiye Etfal Research and Training Hospital, İstanbul, Turkey

DOI: 10.4328/ACAM.22096 Received: 2024-01-15 Accepted: 2024-03-05 Published Online: 2024-03-21

Corresponding Author: Narin Ece Çakmak, Department of Obstetrics and Gynecology, Şişli Hamidiye Etfal Research and Training Hospital, 34470, İstanbul, Turkey. E-mail: rol.narinece@gmail.com P: +90 533 380 35 47 Corresponding Author ORCID ID: https://orcid.org/0000-0001-5497-4490 Other Authors ORCID ID: Burak Çakmak, https://orcid.org/0000-0001-8371-6183 . Gül Özel Doğan, https://orcid.org/0000-0001-9555-1128 . Alev Atış Aydın, https://orcid.org/0000-0002-8504-5755

This study was approved by the Ethics Committee of Şişli Hamidiye Etfal Training and Research Hospital (Date: 2023-02-07, No: 3797)

Evaluation of the relationship between disease severity and the leptin, adiponectin, and chemerin levels in overweight and obese COVID-19 patients

Gonul Seyda Seydel 1, Inayet Gunturk 2, Cevat Yazıcı 3, Ulas Serkan Topaloglu 4, Esma Eryılmaz Eren 5, Recep Civan Yuksel 6

1 Department of Health Care Services, Nigde Zübeyde Hanım Vocational Faculty of Health Service, Nigde Omer Halisdemir University, Nigde,  2 Department of Midwifery, Zubeyde Hanım Faculty of Health Sciences, Nigde Omer Halisdemir University, Nigde, 3 Department of Medical Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, 4 Department of Internal Medicine, Kayseri City Hospital, Kayseri, 5 Department of Infectious Diseases and Clinical Microbiology, Kayseri City Hospital, Kayseri 6 Department of Intensive Care, Faculty of Medicine, Erciyes University, Kayseri, Turkey

DOI: 10.4328/ACAM.22078 Received: 2023-12-19 Accepted: 2024-02-12 Published Online: 2024-03-22

Corresponding Author: Gonul Seyda Seydel, Department of Health Care Services, Zübeyde Hanım Vocational Faculty of Health Services, Nigde Omer Halisdemir University, 51240, Nigde
Turkey. E-mail: seydaseydel@hotmail.com P: +90 553 351 45 91 Corresponding Author ORCID ID: https://orcid.org/0000-0001-9317-0719

This study was approved by the Ethics Committee of Nigde Omer Halisdemir University (Date: 2021-02-21, No: 23)

Hospital and 1-Year mortality Outcomes in COVID-19 pneumonia

Selvi Askar 1, Muntecep Askar 2, Mehmet Hakan Bilgin 1, Hanifi Yıldız 1, Rasa Beyzaei 3, Sıddık Keskin 4

1 Department of Chest Diseases, Faculty of Medicine, Yuzuncu Yil University, 2 Department of Cardiology, Faculty of Medicine, Van Yuzuncu Yil University, Van Training and Research Hospital, 3 Student, Faculty of Medicine, Van Yuzuncu Yil University, 4 Department of Biostatistics, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey

DOI: 10.4328/ACAM.22082 Received: 2023-12-25 Accepted: 2024-02-12 Published Online: 2024-03-23

Corresponding Author: Selvi Askar, Department of Chest Disease, Faculty of Medicine, Yuzuncu Yil University, 65000, Van, Turkey. E-mail: selviasker@gmail.com P: +90 505 251 47 04 Corresponding Author ORCID ID: https://orcid.org/0000-0003-4077-8549

Comparison of two different device results measuring HbA1c by high performance liquid chromatography (HPLC) method

Ahmet Burak Gurpinar 1, Murat Cihan 2, Tevfik Noyan 1, Erhan Seyfi Demirhan 2

1 Department of Medical Biochemistry, Faculty of Medicine, Ordu University, 2 Department of Medical Biochemistry, Ordu University Training and Research Hospital, Ordu, Turkey

DOI: 10.4328/ACAM.22061 Received: 2023-12-01 Accepted: 2024-01-01 Published Online: 2024-03-26

Corresponding Author: Ahmet Burak Gurpinar, Department of Medical Biochemistry, Faculty of Medicine, Ordu University, Ordu, Turkey. E-mail: abgurp@yahoo.com P: +90 505 477 07 50 Corresponding Author ORCID ID: https://orcid.org/0000-0003-3227-4682

This study was approved by the Ethics Committee of Ordu University (Date: 2023-01-20, No: 2023/27)

The relationship between CD3+ and CD4+ T lymphocyte ratio and rejection & infection in renal transplantation patients

Eyup Kaplan 1, Erkan Demir 2, Ugur Erken 2

1 Department of Urology, Gaziantep City Hospital, Gaziantep, 2 Department of Urology, Faculty of Medicine, Cukurova University, Adana, Turkey

DOI: 10.4328/ACAM.22037 Received: 2023-11-05 Accepted: 2023-12-25 Published Online: 2024-03-26

Corresponding Author: Eyup Kaplan, Department of Urology, Gaziantep City Hospital, Gaziantep, Turkey. E-mail: dreyup001@hotmail.com P: +90 552 655 27 26 Corresponding Author ORCID ID: https://orcid.org/0009-0001-8635-9852

This study was approved by the Ethics Committee of Çukurova University Faculty of Medicine (Date: 2013-04-04, No: 18/5)

Evaluation of sleep quality in rheumatoid arthritis patients

Mehmet Siddik Tuncay 1, Ozlem Sahin 2, Murat Semiz 3, Esra Semiz 4, Bulent Alim 2, Halil Peksen 5, Salih Salihoglu 5, Muhammed Fatih Sabuncu 1, Mehmet Salih Kilic 6, Ali Tavasli 7

1 Department of Physical Medicine and Rehabilitation, Liv Hospital, Gaziantep, 2 Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cumhuriyet University, Sivas, 3 Department of Psychiatry, Gulhane Military Medical Academy, Faculty of Medicine, Ankara, 4 Department of Physical Medicine and Rehabilitation, Halil Şivgin Çubuk State Hospital, Ankara, 5 Department of Physical Medicine and Rehabilitation, Sivas Numune Hospital, Sivas, 6 Department of Internal Medicine, Bossan Hospital, Gaziantep, 7 Department of Forensic Medicine, Branch Office, Faculty of Medicine, Gaziantep, Turkey

DOI: 10.4328/ACAM.22050 Received: 2023-11-15 Accepted: 2024-01-01 Published Online: 2024-03-27

Corresponding Author: Mehmet Siddik Tuncay, Department of Physical Medicine and Rehabilitation, Liv Hospital, Gaziantep, Turkey. E-mail: mehmet_s_tuncay@hotmail.com P: +90 541 276 63 49 Corresponding Author ORCID ID: https://orcid.org/0000-0002-8998-6552

This study was approved by the Ethics Committee of Cumhuriyet University (Date: 2013-02-12, No: 2013-02/11)

Assessment of timing of hydrocortisone treatment and vasoactive inotrope scores in pediatric septic shock cases

Gülhan Atakul, Selçuk Sinan Çelik, Merve Kökkülünk, Ece Demirbaş, Özlem Saraç Sandal, Utku Karaarslan, Hasan Ağın

Department of Pediatric Intensive Care Unit, University of Health Sciences, Dr. Behçet Uz Children’s Diseases and Surgery Training and Research Hospital, İzmir, Turkey

DOI: 10.4328/ACAM.22126 Received: 2024-01-26 Accepted: 2024-03-19 Published Online: 2024-03-28

Corresponding Author: Gülhan Atakul, Department of Pediatric Intensive Care Unit, University of Health Sciences, Dr. Behçet Uz Children’s Diseases and Surgery Training and Research Hospital, İzmir, Turkey. E-mail: gulhanatakul@gmail.com P: +90 505 878 00 16 Corresponding Author ORCID ID: https://orcid.org/0000-0002-3832-9691

Other Authors ORCID ID: Selçuk Sinan, https://orcid.org/0000-0002-2208-5549 . Merve Kökkülünk, https://orcid.org/0009-0009-0969-6335 . Ece Demirbaş, https://orcid.org/0009-0004-8872-611X, Özlem Saraç Sandal, https://orcid.org/0000-0003-2684-0625 . Utku Karaarslan, https://orcid.org/0000-0002-3267-6983 . Hasan Ağın, https://orcid.org/0000-0003-3306-8899

This study was approved by the Ethics Committee of Izmir Dr. Behçet Uz Pediatrics and Surgery Training and Research Hospital Clinical Research (Date: 2023-08-20, No: 165)

The effect of regional and general anaesthesia on cerebral oxygenation in shoulder arthroscopy

Arzu Acikel 1, Ismet Topcu 1, Tulun Ozturk 1, Gonul Tezcan Keles 1, Tackin Ozalp 2

1 Department of Anaesthesiology and Reanimation, 2 Department of Orthopaedics and Traumatology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey

DOI: 10.4328/ACAM.22076 Received: 2023-12-22 Accepted: 2024-02-12 Published Online: 2024-03-28

Corresponding Author: Arzu Acikel, Department of Anaesthesiology and Reanimation, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey. E-mail: arzuacikel@yahoo.com P: +90 537 208 34 08 Corresponding Author ORCID ID: https://orcid.org/0000-0002-6246-9731

This study was approved by the Ethics Committee of Manisa Celal Bayar University, Faculty of Medicine (Date: 2015-03-05, No: 20478486-112)

Examination of the relationship between variants in the gene region encoding soluble epoxy hydrolase enzyme hydrolytic activity and type 2 diabetes

Esma Özmen1,6, Durmuş Ayan1, Çağatay Emir Önder2, Dilara Fatma Akın3, Burcu Köse4, İsmail Sarı5, Cevat Yazıcı6

1 Department of Biochemistry, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde, 2 Department of Endocrinology, Ankara Training and Research Hospital, Health Scıences Unıversıty, Ankara, Turkey, 3 Department of Biology, Faculty of Medicine, Nigde Omer Halisdemir University, Nigde, 4 Department of Biotechnology, Faculty of Science Literature, Nigde Omer Halisdemir University, Nigde, 5 Department of Biochemistry, Faculty of Medicine, Kırklareli University, Kırklareli, 6 Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey

DOI: 10.4328/ACAM.22100 Received: 2024-01-09 Accepted: 2024-02-29 Published Online: 2024-03-29

Corresponding Author: Esma Ozmen, Department of Medical Biochemistry, Faculty of Medicine, Niğde Ömer Halisdemir University, 51240, Niğde, Turkey. E-mail: ozmenesma07@gmail.com P: +90 530 960 81 03 Corresponding Author ORCID ID: https://orcid.org/0000-0003-3223-6854

Other Authors ORCID ID: Durmuş Ayan, https://orcid.org/0000-0003-2615-8474 . Çağatay Emir Önder, https://orcid.org/0000-0002-0293-2309 . Dilara Fatma Akin, https://orcid.org/0000-0002-0903-0017 . Burcu Köse, https://orcid.org/0000-0003-1068-0196 . İsmail Sari, https://orcid.org/0000-0003-3732-2102 . Cevat Yazici, https://orcid.org/0000-0003-0625-9542

This study was approved by the Ethics Committee of Niğde Ömer Halisdemir University Non-Interventional (Date: 2022-12-22, No: 2022/116)

Predictors of mortality in lung cancer patients hospitalized with community-acquired pneumonia

Kaan Kara 1, Eyyup Cavdar 2

1 Department of Chest Desease, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, İstanbul, 2 Department of Oncology, Adiyaman Training and Research Hospital, Adiyaman, Turkey

DOI: 10.4328/ACAM.22068 Received: 2023-12-09 Accepted: 2024-01-22 Published Online: 2024-03-29

Corresponding Author:Kaan Kara, Department of Chest Desease, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, İstanbul, Turkey. E-mail: kaankara3643@yahoo.com P: +90 505 674 09 62 Corresponding Author ORCID ID: https://orcid.org/0000-0001-5896-2497

This study was approved by the Ethics Committee of Yedikule Chest Diseases and Chest Surgery Training and Research Hospital (Date: 2022-08-18, No: 2022-267)

Determination of potential drug-drug interactions with different interaction software programs in elderly patients over 85 in a community pharmacy setting: A cross-sectional study

Harun Kızılay 1, Cengizhan Ceylan 2

1 Department of Pharmacology, 2 Department of Clinical Pharmacy, Faculty of Pharmacy, Selcuk University, Konya, Turkey

DOI: 10.4328/ACAM.22106 Received: 2024-01-13 Accepted: 2024-03-05 Published Online: 2024-04-02

Corresponding Author: Harun Kızılay, Department of Pharmacology, Faculty of Pharmacy, Selcuk University, Konya, Turkey. E-mail: harunkizilay@gmail.com P: +90 532 307 77 41
Corresponding Author ORCID ID: https://orcid.org/0000-0003-3660-0721

Other Author ORCID ID: Cengizhan Ceylan, https://orcid.org/0000-0003-4164-9212

This study was approved by the Local Committee of Selçuk University Faculty of Medicine (Date: 2022-06-22, No: 304008)

Clinical outcomes of thoracic trauma in pediatric patients: An examination of admissions to the department of thoracic surgery

Mesut Buz 1, Selime Kahraman 2, Attila Özdemir 1, Berk Çimenoğlu 1, Talha Doğruyol 1, Recep Demirhan 1

1 Department of Thoracic Surgery, Kartal Dr. Lütfi Kırdar City Hospital, 2 Department of Thoracic Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey

DOI: 10.4328/ACAM.22135 Received: 2024-02-02 Accepted: 2024-03-19 Published Online: 2024-04-03

Corresponding Author: Mesut Buz, 1 Department of Thoracic Surgery, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul, Turkey. E-mail: mesutbuzmd@gmail.com P: +90 530 402 21 66
Corresponding Author ORCID ID: https://orcid.org/0000-0003-1899-8983

Other Authors ORCID ID: Selime Kahraman, https://orcid.org/0000-0002-0973-9624 . Attila Özdemir, https://orcid.org/0000-0002-4319-1594 . Berk Çimenoğlu, https://orcid.org/0000-0002-9123-8203 . Talha Doğruyol, https://orcid.org/0000-0003-0875-8409 . Recep Demirhan, https://orcid.org/0000-0003-4424-5918

This study was approved by the Ethics Committee of Kartal Dr. Lütfi Kırdar City Hospital (Date: 2023-04-27, No: 2023/514/248/15)

Factors ınfluencing mortality after cardiopulmonary resuscitation; never give up!

Elvan Tekir Yılmaz 1, Bilge Olgun Keleş 1, İskender Aksoy 2

1 Department of Anesthesiology and Reanimation, 2 Department of Emergency Medicine, Faculty of Medicine, Giresun University, Giresun, Turkey

DOI: 10.4328/ACAM.22134 Received: 2024-02-01 Accepted: 2024-03-19 Published Online: 2024-04-03

Corresponding Author: Elvan Tekir Yilma, Department of Anesthesiology and Reanimation, Faculty of Medicine, Giresun University, Giresun, Turkey. E-mail: elvanty28@hotmail.com P: +90 505 646 64 85 Corresponding Author ORCID ID: https://orcid.org/0000-0001-8631-2520

Other Authors ORCID ID: Bilge Olgun Keleş, https://orcid.org/0000-0002-8912-6317 . İskender Aksoy, https://orcid.org/0000-0002-4426-3342

This study was approved by the Ethics Committee of Giresun University Training Research Hospital (Date: 2023-12-04, No: 26)

Is there a relationship between knee osteoarthritis and osteoporosis?

Hatice Ağır

Department of Physical Medicine and Rehabilitation, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey

DOI: 10.4328/ACAM.22085 Received: 2023-12-27 Accepted: 2024-02-12 Published Online: 2024-04-04

Corresponding Author: Hatice Ağır, Department of Physical Medicine and Rehabilitation, Şanlıurfa Training and Research Hospital, Yenice, Eyyübiye, Şanlıurfa, Turkey. E-mail: haticeagir10@hotmail.com P: +90 554 115 25 90 Corresponding Author ORCID ID: https://orcid.org/0000-0003-1606-9224

This study was approved by the Ethics Committee of Harran University, Faculty of Medicine (Date: 2023-11-15, No: HRU/21.20.12)

Comparison of prehospital trauma scores for prediction of mortality

Yıldız Yıldırımer Çelik 1, Gülşah Çıkrıkçı Işık 2, Eren Usul 3, Hakan Cenci 4, Ali Şahin 3

1 Department of Emergency Medicine, Ankara City Hospital, 2 Department of Emergency Medicine, Health Sciences University, Keçiören Training and Research Hospital, 3
Department of Emergency Medicine, Ankara Etlik City Hospital, 4 Department of Ambulance Service, Ankara Provincial Health Directorate, Ankara, Turkey

DOI: 10.4328/ACAM.21764 Received: 2023-05-24 Accepted: 2023-07-03 Published Online: 2024-04-04

Corresponding Author: Author: Yıldız Yıldırımer Çelik, Department of Emergency Medicine, Ankara City Hospital, Ankara, Turkey. E-mail: yildiz_yildirimer@hotmail.com P: +90 507 615 85 43 Corresponding Author ORCID ID: https://orcid.org/0000-0001-6437-5870

This study was approved by the Ethics Committee of Dışkapı Yıldırım Beyazıt Training and Research Hospital (Date: 2022-09-12, No: 146/05)

Extracellular vesicles mirna-126: A potential therapeutic role in type i diabetic rat model

Shaimaa Saeed Ahmed Ahmed Mostafa 1, Maha Abdel Kader Hegazi 1, Doaa A. Abdelmonsif 2, Seham Z. Nassar 1, Samiha Mahmoud Ahmed Elsayed 1

1 Department of Physiology 2 Department of Biochemistry, Faculty of Medicine, Alexandria University, Alexnadria, Egypt

DOI: 10.4328/ACAM.22113 Received: 2024-01-16 Accepted: 2024-03-05 Published Online: 2024-04-04

Corresponding Author: Shaimaa Saeed Ahmed Ahmed Mostafa, Department of Physiology, Faculty of Medicine, Alexandria University, 21561, Alexnadria, Egypt. E-mail: shimaa.ahmed@alexmed.edu.eg P: +20 114 995 69 32 Corresponding Author ORCID ID: https://orcid.org/0000-0003-2772-5143

Other Authors ORCID ID: Maha Abdel Kader Hegazi, https://orcid.org/0000-0002- 8240-3852 . Doaa A. Abdelmonsif, https://orcid.org/0000-0002-6859-1156
Seham Z. Nassar, https://orcid.org/0000-0002-8129-034X . Samiha Mahmoud Ahmed Elsayed, https://orcid.org/0000-0002-3793-1613

This study was approved by the Ethics Committee of Alexandria Faculty of Medicine (Date: 2021-6-27, IRB No: 00012098- FWA No: 00018699)

Information received and usefulness of the sources of information to cancer patients at an oncology hospital in Turkey

Büşra İnce 1, Pınar Atak Çakır 2, Serkan Eti 3, Fatma Mutluay 4

1 Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bandirma Onyedi Eylul University, 2 Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul Medipol University, 3 Department of Computer Programming, Vocational School of Health Sciences, Istanbul Medipol University, 4 Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul Medipol University, Istanbul, Turkey

DOI: 10.4328/ACAM.22018 Received: 2023-10-20 Accepted: 2024-02-29 Published Online: 2024-04-05

Corresponding Author: Pınar Atak Çakır, Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul Medipol University, Istanbul, Turkey. E-mail: pnaratak9340@gmail.com P: +90 536 056 94 04 Corresponding Author ORCID ID: https://orcid.org/0000-0001-5640-2998

This study was approved by the Ethics Committee of Istanbul Medipol University Non-Interventional Clinical Research Ethics Committee (Date: 2018-08-15, No: 446)

The epidemiology of pediatric trauma in the emergency department of a trauma center: An observational study

Nurgül Akça 1, Ömer Faruk Demir 2, Secdegül Coşkun Yaş 3

1 Department of Emergency Medicine, Karabuk University, Karabuk Training and Research Hospital, Karabük, 2 Department of Emergency Medicine, University of Health Sciences, Dıskapı Yıldırım Beyazıt Training and Research Hospital, Ankara, 3 Department of Emergency Medicine, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey

DOI: 10.4328/ACAM.22079 Received: 2023-12-20 Accepted: 2024-02-23 Published Online: 2024-04-05

Corresponding Author: Ömer Faruk Demir, Department of Emergency Medicine, University of Health Sciences, Dıskapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
E-mail: demirof@yahoo.com P: +90 530 665 08 02 Corresponding Author ORCID ID: https://orcid.org/0000-0002-2416-0274

This study was approved by the Ethics Committee of University of Health Sciences Diskapi Yildirim Beyazit Training and Research Hospital (Date: 2020-07-20, No: 92/14)

Case Report

Osteochondroma: In a rare location inside of the skull

Hakan Şahinoğlu, Sırrı Gürhan Çelen, Murat Baykara

Department of Radiology, Istanbul Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey

DOI: 10.4328/ACAM.22046 Received: 2023-11-13 Accepted: 2024-01-22 Published Online: 2024-03-29

Corresponding Author: Hakan Şahinoğlu, Department of Radiology, Istanbul Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey. E-mail: drhakansahinoglu@gmail.com P: +90 535 332 66 64 Corresponding Author ORCID ID: https://orcid.org/0000-0001-8094-9109

Review Article

The role of obesity in the development of cardiovascular diseases: An overview of human and rodent studies

Yasemin Hacanlı

Department of Cardiovascular Surgery, Faculty of Medicine, Harran University, Şanlıurfa, Turkey

DOI: 10.4328/ACAM.22062 Received: 2023-12-01 Accepted: 2024-01-08 Published Online: 2024-02-17

Corresponding Author: Yasemin Hacanlı, Department of Cardiovascular Surgery, Faculty of Medicine, Harran University, Şanlıurfa, Turkey. E-mail: yaseminhacan@hotmail.com P: +90 506 700 27 00 Corresponding Author ORCID ID: https://orcid.org/0000-0002-4427-8149